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| rdf:type
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| Description
| - Background: High mobility group box 1 (HMGB1) is a nuclear protein which is released from cells during cell necrosis or actively as a late cytokine. Gastric necrosis is one of the major complication and negative prognostic factor in dogs with gastric dilatation-volvulus syndrome (GDV). Objective: The aim of this study was to determinate diagnostic value of HMGB1 for detection of gastric necrosis in dogs with GDV. Methods: Fifty-four dogs with GDV were enrolled in this prospective study. Blood was collected before surgery from jugular vein and HMGB1 was detected using ELISA method (HMGB1, IBL International GmbH, Germany) from serum. Results: Sixteen dogs had macroscopically evident gastric necrosis and underwent partial gastrectomy or euthanasia. Thirty-eight dogs did not have gastric necrosis and were discharged from the hospital after successful treatment. Dogs with gastric necrosis had significantly higher HMGB1 levels (median 9.4 ng/ml, min-max 1.1-36.1 ng/ml) in comparison to those who had intact gastric wall (4.7 ng/ml, detection limit-16.5 ng/ml, p{0.001). Receiver operator curve was constructed and optimal cut-off for detection of gastric necrosis was set }6.1 ng/ml with 75% sensitivity and 78% specificity. Area under the ROC curve was 0.795 (95% confidence interval: 0.662-0.893, p=0.0001). Conclusion: HMGB1 is a useful marker of gastric necrosis in dogs with gastric dilatation and volvulus.
- Background: High mobility group box 1 (HMGB1) is a nuclear protein which is released from cells during cell necrosis or actively as a late cytokine. Gastric necrosis is one of the major complication and negative prognostic factor in dogs with gastric dilatation-volvulus syndrome (GDV). Objective: The aim of this study was to determinate diagnostic value of HMGB1 for detection of gastric necrosis in dogs with GDV. Methods: Fifty-four dogs with GDV were enrolled in this prospective study. Blood was collected before surgery from jugular vein and HMGB1 was detected using ELISA method (HMGB1, IBL International GmbH, Germany) from serum. Results: Sixteen dogs had macroscopically evident gastric necrosis and underwent partial gastrectomy or euthanasia. Thirty-eight dogs did not have gastric necrosis and were discharged from the hospital after successful treatment. Dogs with gastric necrosis had significantly higher HMGB1 levels (median 9.4 ng/ml, min-max 1.1-36.1 ng/ml) in comparison to those who had intact gastric wall (4.7 ng/ml, detection limit-16.5 ng/ml, p{0.001). Receiver operator curve was constructed and optimal cut-off for detection of gastric necrosis was set }6.1 ng/ml with 75% sensitivity and 78% specificity. Area under the ROC curve was 0.795 (95% confidence interval: 0.662-0.893, p=0.0001). Conclusion: HMGB1 is a useful marker of gastric necrosis in dogs with gastric dilatation and volvulus. (en)
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| Title
| - Diagnostic value of HMGB1 for detection of gastric necrosis in dogs with gastric dilatation-volvulus syndrome.
- Diagnostic value of HMGB1 for detection of gastric necrosis in dogs with gastric dilatation-volvulus syndrome. (en)
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| skos:prefLabel
| - Diagnostic value of HMGB1 for detection of gastric necrosis in dogs with gastric dilatation-volvulus syndrome.
- Diagnostic value of HMGB1 for detection of gastric necrosis in dogs with gastric dilatation-volvulus syndrome. (en)
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| skos:notation
| - RIV/62157124:16170/13:43872490!RIV14-MSM-16170___
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/62157124:16170/13:43872490
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - necrosis; GDV; HMGB1 (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Raušerová-Lexmaulová, Leona
- Uhríková, Ivana
- Řeháková, Kristina
- Doubek, Jaroslav
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| http://localhost/t...ganizacniJednotka
| |
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