About: Caspase-7 participates in differentiation of cells forming dental hard tissues

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices. Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices. (en)
Title	Caspase-7 participates in differentiation of cells forming dental hard tissues Caspase-7 participates in differentiation of cells forming dental hard tissues (en)
skos:prefLabel	Caspase-7 participates in differentiation of cells forming dental hard tissues Caspase-7 participates in differentiation of cells forming dental hard tissues (en)
skos:notation	RIV/62157124:16170/13:43871764!RIV14-GA0-16170___
http://linked.open...avai/predkladatel	Fakulta veterinárního lékařství
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP304/11/1418), P(GAP502/12/1285)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Matalová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Fakulta veterinárního lékařství
http://linked.open...dnocenehoVysledku	64384
http://linked.open...ai/riv/idVysledku	RIV/62157124:16170/13:43871764
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	dens; caspase 7 (en)
http://linked.open.../riv/klicoveSlovo	caspase 7 dens
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DD9AD967E249]
http://linked.open...i/riv/nazevZdroje	Development Growth & Differentiation
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Differentiation of human embryonic stem cells into odontogenic lineages Apoptotic and non-apoptotic functions of caspases in hard tissue formation
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Vandenabeele, Peter Matalová, Eva Tucker, Abigail S Švandová, Eva Healy, Christopher Lesot, Hervé Sharpe, Paul T Vanden Beghe, Thomas
http://linked.open...ain/vavai/riv/wos	000320470700003
issn	0012-1592
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/dgd.12066
http://localhost/t...ganizacniJednotka	16170

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