About: gamadelta T lymphocytes are recruited into the inflamed uterus of bitches suffering from pyometra

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Very little is known about the occurrence of immune system cells in the canine uterus. The aim of this study was to generate information about lymphocyte subsets that are present in the healthy canine uterus and that are recruited under inflammatory conditions caused by pyometra. Using immunohistochemistry and flow cytometry, a significant influx of gamadelta T lymphocytes was found in pyometra samples mainly due to recruitment of gamadelta+/CD8? T lymphocytes. The relative expression of genes encoding selected cytokines/chemokines was evaluated in samples from healthy and pyometra-affected uteri. Expression of pro-inflammatory cytokines (including IL-1beta, TNF-alfa, IL-8, IL-17 and IFN-gama) and chemokines (including CXCL10, CCL4 and CCL5) was upregulated in pyometra samples confirming the presence of inflammation. In contrast, the expression of the homeostatic chemokine CCL25 and of the anti-inflammatory cytokine IL-10 was downregulated and unchanged, respectively. Very little is known about the occurrence of immune system cells in the canine uterus. The aim of this study was to generate information about lymphocyte subsets that are present in the healthy canine uterus and that are recruited under inflammatory conditions caused by pyometra. Using immunohistochemistry and flow cytometry, a significant influx of gamadelta T lymphocytes was found in pyometra samples mainly due to recruitment of gamadelta+/CD8? T lymphocytes. The relative expression of genes encoding selected cytokines/chemokines was evaluated in samples from healthy and pyometra-affected uteri. Expression of pro-inflammatory cytokines (including IL-1beta, TNF-alfa, IL-8, IL-17 and IFN-gama) and chemokines (including CXCL10, CCL4 and CCL5) was upregulated in pyometra samples confirming the presence of inflammation. In contrast, the expression of the homeostatic chemokine CCL25 and of the anti-inflammatory cytokine IL-10 was downregulated and unchanged, respectively. (en)
Title	gamadelta T lymphocytes are recruited into the inflamed uterus of bitches suffering from pyometra gamadelta T lymphocytes are recruited into the inflamed uterus of bitches suffering from pyometra (en)
skos:prefLabel	gamadelta T lymphocytes are recruited into the inflamed uterus of bitches suffering from pyometra gamadelta T lymphocytes are recruited into the inflamed uterus of bitches suffering from pyometra (en)
skos:notation	RIV/62157124:16170/12:43871260!RIV13-MSM-16170___
http://linked.open...avai/predkladatel	Fakulta veterinárního lékařství
http://linked.open...avai/riv/aktivita	O
http://linked.open...avai/riv/aktivity	O
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Matiašovic, Ján Vitásek, Roman Bartošková, Alena Faldyna, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Fakulta veterinárního lékařství
http://linked.open...dnocenehoVysledku	137690
http://linked.open...ai/riv/idVysledku	RIV/62157124:16170/12:43871260
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	gamadelta Lymphocytes; Chemokines; Flow cytometry; Lymphocyte subsets; Canine (en)
http://linked.open.../riv/klicoveSlovo	Chemokines Canine Lymphocyte subsets gamadelta Lymphocytes Flow cytometry
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[EB2B43032C2D]
http://linked.open...i/riv/nazevZdroje	Veterinary Journal
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	194
http://linked.open...iv/tvurceVysledku	Faldyna, Martin Levá, Lenka Matiašovic, Ján Štěpánová, Hana Bartošková, Alena Vitásek, Roman Ondráčková, Petra Moore, Peter F. Oreškovič, Zrinka Turánek-Knötigová, Pavlína Vicenová, Monika
issn	1090-0233
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	16170
is http://linked.open...avai/riv/vysledek of	gamadelta T lymphocytes are recruited into the inflamed uterus of bitches suffering from pyometra

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