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  • The aim of the study was to assess the efficacy of using a Gn-RH agonist implant (deslorelin 4.7 mg, Suprelorin(R)) to control sexual activity of male cats and reestablishment of sexual function after the implant removal four months after placement. Using a control group (Group 1, n = 5), 22 domestic tomcats were given the implant subcutaneously in the region of the right shoulder blade and were then divided into two treatment groups. Animals in Group 2 (n = 14) were observed from the date of implant surgery and the observation lasted for four months. In Group 3 (n = 8) all animals were monitored from the date of implant surgery. Then, after four months, all implants were removed and the toms were observed for a further four months. In all animals during their first visit and then in one-month intervals, changes in testosterone concentrations were assessed before (T0) and four hours after (T4) human chorionic gonadotropin (HCG) administration and testis size was measured. In all tomcats, semen collection was performed, using an electroejaculator, in the course of the first visit and then in two-month intervals or at the end of observation. Total sperm count was determined in each semen sample. Two to four animals were castrated at weeks 4, 8, 12, 16, 20, 24, 28 and 32 and histological assessment of the testes was performed. By evaluation of 200 cross-sections of seminiferous tubules, the degree of spermatogenic suppression was assessed and animals in groups 2 and 3 were assigned into groups according to the majority of tubules with the most developed germ cell observed: G1, spermatocytes; G2, round spermatids; G3, elongating spermatids and G4, elongated spermatids. The mean area of Leydig-cell nuclei was calculated. In animals in Group 2, suppression after implant insertion was monitored. T4 concentrations, testis size, and total sperm count gradually decreased (P { 0.01; P { 0.01; and P { 0.05 respectively) within four months after implantation.
  • The aim of the study was to assess the efficacy of using a Gn-RH agonist implant (deslorelin 4.7 mg, Suprelorin(R)) to control sexual activity of male cats and reestablishment of sexual function after the implant removal four months after placement. Using a control group (Group 1, n = 5), 22 domestic tomcats were given the implant subcutaneously in the region of the right shoulder blade and were then divided into two treatment groups. Animals in Group 2 (n = 14) were observed from the date of implant surgery and the observation lasted for four months. In Group 3 (n = 8) all animals were monitored from the date of implant surgery. Then, after four months, all implants were removed and the toms were observed for a further four months. In all animals during their first visit and then in one-month intervals, changes in testosterone concentrations were assessed before (T0) and four hours after (T4) human chorionic gonadotropin (HCG) administration and testis size was measured. In all tomcats, semen collection was performed, using an electroejaculator, in the course of the first visit and then in two-month intervals or at the end of observation. Total sperm count was determined in each semen sample. Two to four animals were castrated at weeks 4, 8, 12, 16, 20, 24, 28 and 32 and histological assessment of the testes was performed. By evaluation of 200 cross-sections of seminiferous tubules, the degree of spermatogenic suppression was assessed and animals in groups 2 and 3 were assigned into groups according to the majority of tubules with the most developed germ cell observed: G1, spermatocytes; G2, round spermatids; G3, elongating spermatids and G4, elongated spermatids. The mean area of Leydig-cell nuclei was calculated. In animals in Group 2, suppression after implant insertion was monitored. T4 concentrations, testis size, and total sperm count gradually decreased (P { 0.01; P { 0.01; and P { 0.05 respectively) within four months after implantation. (en)
Title
  • Reversible suppression of sexual activity in tomcats with deslorelin implant
  • Reversible suppression of sexual activity in tomcats with deslorelin implant (en)
skos:prefLabel
  • Reversible suppression of sexual activity in tomcats with deslorelin implant
  • Reversible suppression of sexual activity in tomcats with deslorelin implant (en)
skos:notation
  • RIV/62157124:16170/12:43871256!RIV13-MSM-16170___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S, Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 165392
http://linked.open...ai/riv/idVysledku
  • RIV/62157124:16170/12:43871256
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Histological evaluation; Semen collection; Testis size; Male cat; GnRH-agonist (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [AC308AF89958]
http://linked.open...i/riv/nazevZdroje
  • Teriogenology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 78
http://linked.open...iv/tvurceVysledku
  • Čížek, Petr
  • Bartošková, Alena
  • Novotný, Robert
  • Přinosilová, Petra
  • Vitásek, Roman
  • Janošovská, Michaela
http://linked.open...ain/vavai/riv/wos
  • 000307622200019
http://linked.open...n/vavai/riv/zamer
issn
  • 0093-691X
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.theriogenology.2012.03.035
http://localhost/t...ganizacniJednotka
  • 16170
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