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  • This study was undertaken to evaluate safety and biocompatibility of a novel biodegradable polydioxanone stent in a rabbit tracheal model. Metallic and silicone stents represent standard therapeutic approaches for hollow organ stenosis, although complications have been reported repeatedly. Biodegradable stents could reduce the risks associated with this procedure while still achieving the purpose of maintaining lumen patency. METHODS: A commercially available polydioxanone suture strand with a long safety record was used to manufacture the self-expanding stents. The polydioxanone stents were then implanted bronchoscopically and under fluoroscopic guidance into the tracheas of white rabbits (N = 25). Periodic clinical examination was performed. Histopathologic examination concluded the study for the 5 experimental groups at 3, 4, 5, 10, and 15 weeks after implantation.
  • This study was undertaken to evaluate safety and biocompatibility of a novel biodegradable polydioxanone stent in a rabbit tracheal model. Metallic and silicone stents represent standard therapeutic approaches for hollow organ stenosis, although complications have been reported repeatedly. Biodegradable stents could reduce the risks associated with this procedure while still achieving the purpose of maintaining lumen patency. METHODS: A commercially available polydioxanone suture strand with a long safety record was used to manufacture the self-expanding stents. The polydioxanone stents were then implanted bronchoscopically and under fluoroscopic guidance into the tracheas of white rabbits (N = 25). Periodic clinical examination was performed. Histopathologic examination concluded the study for the 5 experimental groups at 3, 4, 5, 10, and 15 weeks after implantation. (en)
Title
  • Novel biodegradable polydioxanone stents in a rabbit airway model
  • Novel biodegradable polydioxanone stents in a rabbit airway model (en)
skos:prefLabel
  • Novel biodegradable polydioxanone stents in a rabbit airway model
  • Novel biodegradable polydioxanone stents in a rabbit airway model (en)
skos:notation
  • RIV/62157124:16170/12:43870973!RIV13-MSM-16170___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 154773
http://linked.open...ai/riv/idVysledku
  • RIV/62157124:16170/12:43870973
http://linked.open...riv/jazykVysledku
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  • model; airway; rabbit; stents; polydioxanone; biodegradable; Novel (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [8817F0AE47AF]
http://linked.open...i/riv/nazevZdroje
  • Journal of thoracic and cardiovascular surgery
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 143
http://linked.open...iv/tvurceVysledku
  • Crha, Michal
  • Nečas, Alois
  • Novotný, Ladislav
  • Raušer, Petr
  • Hep, Aleš
  • Mišík, Jan
  • Vondrys, David
http://linked.open...ain/vavai/riv/wos
  • 000299318000032
issn
  • 0022-5223
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.jtcvs.2011.08.002
http://localhost/t...ganizacniJednotka
  • 16170
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