About: Caspase Inhibition and N6-Benzyladenosine-lnduced Apoptosis in Hl-60 Cells

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About: Caspase Inhibition and N6-Benzyladenosine-lnduced Apoptosis in Hl-60 Cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	As an extension of our recently published work (Mlejnek and Kuglík [2000] J. Cell. Biochem. 77:6-17), the role of caspases in N6-benzylaminopurine riboside (BAPR)-induced apotosis in HL-60 cells was evaluated in this study. Here, BAPR-induced apoptosis was accompanied by activation of caspase-3 and caspase-9. However, when these caspases were selectively inhibited, the progression of BAPR-induced apoptosis was not markedly affected. Besides that, activation of caspase-3 and caspase-9 was found to be rather /ate event in apoptotic process. These results suggested that other caspases might be critically implicated. Indeed, pan-specific caspase inhibitor, Z-VAD-FMK completely prevented DNA cleavage and apoptotic bodies formation. However, Z-VAD-FMK failed to prevent CťiL death and it was incapable to fully counteract the main apoptotic hallmark-chromatin condensation. As an extension of our recently published work (Mlejnek and Kuglík [2000] J. Cell. Biochem. 77:6-17), the role of caspases in N6-benzylaminopurine riboside (BAPR)-induced apotosis in HL-60 cells was evaluated in this study. Here, BAPR-induced apoptosis was accompanied by activation of caspase-3 and caspase-9. However, when these caspases were selectively inhibited, the progression of BAPR-induced apoptosis was not markedly affected. Besides that, activation of caspase-3 and caspase-9 was found to be rather /ate event in apoptotic process. These results suggested that other caspases might be critically implicated. Indeed, pan-specific caspase inhibitor, Z-VAD-FMK completely prevented DNA cleavage and apoptotic bodies formation. However, Z-VAD-FMK failed to prevent CťiL death and it was incapable to fully counteract the main apoptotic hallmark-chromatin condensation. (en)
Title	Caspase Inhibition and N6-Benzyladenosine-lnduced Apoptosis in Hl-60 Cells Caspase Inhibition and N6-Benzyladenosine-lnduced Apoptosis in Hl-60 Cells (en)
skos:prefLabel	Caspase Inhibition and N6-Benzyladenosine-lnduced Apoptosis in Hl-60 Cells Caspase Inhibition and N6-Benzyladenosine-lnduced Apoptosis in Hl-60 Cells (en)
skos:notation	RIV/62156489:_____/01:21100020!RIV/2002/MSM/430002/N
http://linked.open.../vavai/riv/strany	678;689
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 432100001)
http://linked.open...iv/cisloPeriodika	September
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	MLEJNEK, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mendelova univerzita v Brně / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	674963
http://linked.open...ai/riv/idVysledku	RIV/62156489:_____/01:21100020
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	caspase-3; caspase-9; Ac-LEHD-CMK; Z-DEVD-FMK; Z-VAD-FMK; cell death; N6-benzylaminopurine riboside; nuclear apotosis (en)
http://linked.open.../riv/klicoveSlovo	cell death caspase-3 Ac-LEHD-CMK N6-benzylaminopurine riboside Z-DEVD-FMK Z-VAD-FMK caspase-9 nuclear apotosis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F3979AF15548]
http://linked.open...i/riv/nazevZdroje	Journal of Cellular Biochemistry
http://linked.open...in/vavai/riv/obor	GK
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	83
http://linked.open...iv/tvurceVysledku	Mlejnek, Petr
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20432100001
issn	1097-4644
number of pages	12 (xsd:int)

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