About: Analysis of micro RNAs expression in cell lines derieved from prostate carcinoma

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MiRNAs constitute a large class of single-stranded RNA molecules of 19 to 25 nucleotides that are involved in post-transcriptional gene silencing. MiRNAs not only regulate various developmental and physiologic processes but also are involved in cancer development and can play a role as an important biomarkers. The aim of this study was to determinate the expression levels of selected miRNA in the non-tumor PNT1A line in comparison with tumor lines 22Rv1, PC-3, and LNCaP. We used the TaqMan Gene Expression Assays and quantitative RT-PCR. We observed significantly higher (p<0.01) expression of miRNA 23a in all tumor lines compared to non-tumor PNT1A. Significantly higher (p<0.01) expression of miRNA 224 in 22Rv1 line compared to others and significantly higher (p<0.01) expression of miRNA 375 in all tumor lines in comparison with non-tumor PNT1A MiRNAs constitute a large class of single-stranded RNA molecules of 19 to 25 nucleotides that are involved in post-transcriptional gene silencing. MiRNAs not only regulate various developmental and physiologic processes but also are involved in cancer development and can play a role as an important biomarkers. The aim of this study was to determinate the expression levels of selected miRNA in the non-tumor PNT1A line in comparison with tumor lines 22Rv1, PC-3, and LNCaP. We used the TaqMan Gene Expression Assays and quantitative RT-PCR. We observed significantly higher (p<0.01) expression of miRNA 23a in all tumor lines compared to non-tumor PNT1A. Significantly higher (p<0.01) expression of miRNA 224 in 22Rv1 line compared to others and significantly higher (p<0.01) expression of miRNA 375 in all tumor lines in comparison with non-tumor PNT1A (en)
Title	Analysis of micro RNAs expression in cell lines derieved from prostate carcinoma Analysis of micro RNAs expression in cell lines derieved from prostate carcinoma (en)
skos:prefLabel	Analysis of micro RNAs expression in cell lines derieved from prostate carcinoma Analysis of micro RNAs expression in cell lines derieved from prostate carcinoma (en)
skos:notation	RIV/62156489:43210/12:00190269!RIV13-GA0-43210___
http://linked.open...avai/predkladatel	Agronomická fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP102/11/1068)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Sztalmachová, Markéta Babula, Petr Adam, Vojtěch Masařík, Michal Kizek, René
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mendelova univerzita v Brně / Agronomická fakulta
http://linked.open...dnocenehoVysledku	122176
http://linked.open...ai/riv/idVysledku	RIV/62156489:43210/12:00190269
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RNA; biomarker; cell lines (en)
http://linked.open.../riv/klicoveSlovo	cell lines RNA biomarker
http://linked.open...ontrolniKodProRIV	[8969C01B0DDA]
http://linked.open...v/mistoKonaniAkce	Brno, Česká republika
http://linked.open...i/riv/mistoVydani	Mendelova univerzita v Brně
http://linked.open...i/riv/nazevZdroje	XII. Pracovní setkání fyzikálních chemiků a elektrochemiků
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Nano-Electro-Bio-Tools for Biochemical and Molecularly-Biological Studies of Eukaryotic Cells (NanoBioTECell)
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Babula, Petr Gumulec, Jaromír Hlavna, M. Kizek, René Masařík, Michal Sztalmachová, Markéta Raudenska, Kristyna Raudenská, M. Tanhauserova, V.
http://linked.open...vavai/riv/typAkce	CST - Celostátní
http://linked.open.../riv/zahajeniAkce	2012-01-01 (xsd:date)
number of pages	3 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Mendelova zemědělská a lesnická univerzita v Brně
https://schema.org/isbn	978-80-7375-618-5
http://localhost/t...ganizacniJednotka	43210
is http://linked.open...avai/riv/vysledek of	Analysis of micro RNAs expression in cell lines derieved from prostate carcinoma

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