About: Determination of GSH and GSSG in blood plasma of patiens by HPLC-ED

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Thanks to many chemicals and physical stresses generated by outside environment there still is unpredictable danger of damaging of organism by reactive oxygen species (ROS). Biological harmfulness of ROS is generally given by the subsequent oxidation of essential cellular structures. Organism is defending against ROS by synthesis of small molecules which can neutralize radicals. The most suitable existing organic molecule widespread in whole organism which can decrease effect of ROS is glutathione (GSH). Therefore we interested in changes of GSH levels by oncological patients. We optimized fast and robust method for analysis blood plasma of patients by employment of HPLC with coulometric detection. Our results based on hunderts of analyzed samples shows significant oxidation damage by disbalance between GSH/GSSG ratio. Thanks to many chemicals and physical stresses generated by outside environment there still is unpredictable danger of damaging of organism by reactive oxygen species (ROS). Biological harmfulness of ROS is generally given by the subsequent oxidation of essential cellular structures. Organism is defending against ROS by synthesis of small molecules which can neutralize radicals. The most suitable existing organic molecule widespread in whole organism which can decrease effect of ROS is glutathione (GSH). Therefore we interested in changes of GSH levels by oncological patients. We optimized fast and robust method for analysis blood plasma of patients by employment of HPLC with coulometric detection. Our results based on hunderts of analyzed samples shows significant oxidation damage by disbalance between GSH/GSSG ratio. (en)
Title	Determination of GSH and GSSG in blood plasma of patiens by HPLC-ED Determination of GSH and GSSG in blood plasma of patiens by HPLC-ED (en)
skos:prefLabel	Determination of GSH and GSSG in blood plasma of patiens by HPLC-ED Determination of GSH and GSSG in blood plasma of patiens by HPLC-ED (en)
skos:notation	RIV/62156489:43210/10:00184593!RIV12-MSM-43210___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1M06030), P(GA522/09/0239)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Cernei, Natalia Vladimirovna Adam, Vojtěch Kizek, René Zítka, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mendelova univerzita v Brně / Agronomická fakulta
http://linked.open...dnocenehoVysledku	253752
http://linked.open...ai/riv/idVysledku	RIV/62156489:43210/10:00184593
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	blood plasma; glutathione; coulometric detection (en)
http://linked.open.../riv/klicoveSlovo	glutathione blood plasma coulometric detection
http://linked.open...odStatuVydavatele	IN - Indická republika
http://linked.open...ontrolniKodProRIV	[954C50C0F6B7]
http://linked.open...i/riv/nazevZdroje	Journal of Biochemical Technology
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional genomics and proteomics for crop improvement Cellular and organ responses of plants to the polycyclic aromatic hydrocarbon
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Cernei, Natalia Vladimirovna Horna, Aleš Kizek, René Zítka, Ondřej
issn	0974-2328
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	43210
is http://linked.open...avai/riv/vysledek of	Determination of GSH and GSSG in blood plasma of patiens by HPLC-ED Determination of GSH and GSSG in blood plasma of patiens by HPLC-ED

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