About: Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In the present paper we employed adsorptive transfer stripping technique coupled with chronopotentiometric stripping analysis for determination of metallothionein (MT) in tumor cell lines and differential pulse voltammetry Brdicka reaction for determination of MT in blood serum of patients with head and neck cancer or retinoblastoma, and of rats treated with cisplatin with respect to discuss the role of MT in formation of resistance on treatment with heavy metal based cytostatics. The cisplatin or carboplatin sensitive and resistant neuroblastoma cell lines were derived from the maternal cell line isolated from the bone metastasis of patients with neuroblastoma. Based on the results obtained it can be concluded that level of MT increases with higher dose of platinum based In the present paper we employed adsorptive transfer stripping technique coupled with chronopotentiometric stripping analysis for determination of metallothionein (MT) in tumor cell lines and differential pulse voltammetry Brdicka reaction for determination of MT in blood serum of patients with head and neck cancer or retinoblastoma, and of rats treated with cisplatin with respect to discuss the role of MT in formation of resistance on treatment with heavy metal based cytostatics. The cisplatin or carboplatin sensitive and resistant neuroblastoma cell lines were derived from the maternal cell line isolated from the bone metastasis of patients with neuroblastoma. Based on the results obtained it can be concluded that level of MT increases with higher dose of platinum based (en) Cílem této práce bylo využít adsorbtivní přenosovou techniku rozpouštěcí chronopotenciometrické analýzi pro stanovení metalothioneinu v krevním séru pacientů s nádory krku a hlavy případně pacientů s retoblastomema a myší po aplikaci cysplatiny. Dále stanovení metalothioneinu v nádorových buněčných liniích. Bůněčné linie byly izolovány od pacientů s neuroblastomi. Na základě výsledků jsem vyslovili závěr, že hladina metalothioneinu se zvyšuje po vyší dávce cisplatiny. (cs)
Title	Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease (en) Elektrochemické techniky pro stanovení metalothioneinu v tumorových buněčných liniích a pacientů s nádorovým onemocněním (cs)
skos:prefLabel	Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease (en) Elektrochemické techniky pro stanovení metalothioneinu v tumorových buněčných liniích a pacientů s nádorovým onemocněním (cs)
skos:notation	RIV/62156489:43210/08:00133063!RIV09-AV0-43210___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(IAA401990701)
http://linked.open...iv/cisloPeriodika	14
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Křížková, Soňa Húska, Dalibor Adam, Vojtěch Kizek, René
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mendelova univerzita v Brně / Agronomická fakulta
http://linked.open...dnocenehoVysledku	366105
http://linked.open...ai/riv/idVysledku	RIV/62156489:43210/08:00133063
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cisplatin; metallothionein (en)
http://linked.open.../riv/klicoveSlovo	cisplatin metallothionein
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[18CC268948E6]
http://linked.open...i/riv/nazevZdroje	Electroanalysis
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Hubálek, Jaromír Húska, Dalibor Kizek, René Křížková, Soňa Průša, Richard Trnková, Libuše Fabrik, Ivo
issn	1040-0397
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	43210
is http://linked.open...avai/riv/vysledek of	Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease

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