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| Description
| - Glutathion a metalothionein hrají v organizmu klíčovou roly v detoxifikaci organizmu před různými chemickými látkami. Vzhledem k jejich vyšší afinitě k těžkým kovům udržují jejich homeostázu v organizmu, což je jednou z jejich hlavních fyziologických funkcí. V této práci jsme studovali interakci glutathionu redukovaného a oxidovaného, nitrosoglutathionu a MT s platinovými cytostatiky (cisplatin, carboplatin and oxaliplatin). Použili jsme více voltametrických technik (cyklickou voltametrii, diferenční pulsní voltametrii) v trojelektrodovém uspořádání. Zjistil jsme, že signál GSH se snižoval z přibývající koncentrací těžkého kovu. Navíc přítomnost těžkého kovu katalyzovala rozklad GSNO. MT snižuje terapeutickou koncentraci platinových cytostatik. (cs)
- Glutathione and metallothionein (MT) play a key role in detoxification of chemical compounds coming to an organism. Due to their high affinity to heavy metals, homeostatic control and detoxification of the metals are one of their main physiological functions. Objective. The aim of this work was to study and characterize interactions of glutathiones (reduced GSH, oxidized GSSG and S-nitrosoglutathione GSNO) and MT with platinum group metals and cytostatics (cisplatin, carboplatin and oxaliplatin). Materials and methods. We used different electrochemical techniques (cyclic voltammetry, differential pulse voltammetry and chronopotentiometric stripping analysis). Measurements were performed with AUTOLAB connected to VA-Stand 663, using standard cell with three electrodes. We observed that signal of GSH decreased with increasing concentration of a heavy metal. Moreover, presence of heavy metals catalysed decomposition of GSNO, thus, nitric oxide was released. Conclusion. MT could markedly decrease therap
- Glutathione and metallothionein (MT) play a key role in detoxification of chemical compounds coming to an organism. Due to their high affinity to heavy metals, homeostatic control and detoxification of the metals are one of their main physiological functions. Objective. The aim of this work was to study and characterize interactions of glutathiones (reduced GSH, oxidized GSSG and S-nitrosoglutathione GSNO) and MT with platinum group metals and cytostatics (cisplatin, carboplatin and oxaliplatin). Materials and methods. We used different electrochemical techniques (cyclic voltammetry, differential pulse voltammetry and chronopotentiometric stripping analysis). Measurements were performed with AUTOLAB connected to VA-Stand 663, using standard cell with three electrodes. We observed that signal of GSH decreased with increasing concentration of a heavy metal. Moreover, presence of heavy metals catalysed decomposition of GSNO, thus, nitric oxide was released. Conclusion. MT could markedly decrease therap (en)
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| Title
| - Study of interaction of glutathiones and metallothionein with cytostatics
- Study of interaction of glutathiones and metallothionein with cytostatics (en)
- Studium interakce glutathionu a metalothioneinu s cytostatiky (cs)
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| skos:prefLabel
| - Study of interaction of glutathiones and metallothionein with cytostatics
- Study of interaction of glutathiones and metallothionein with cytostatics (en)
- Studium interakce glutathionu a metalothioneinu s cytostatiky (cs)
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| skos:notation
| - RIV/62156489:43210/06:00103406!RIV07-GA0-43210___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/62156489:43210/06:00103406
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - cisplatin; cytostatics; glutathione (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Adam, Vojtěch
- Beklová, Miroslava
- Kizek, René
- Průša, Richard
- Petrlová, Jitka
- Kukačka, Jiří
- Sures, Bernd
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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