About: Multicomponent and Regioselective Synthesis of Dihydropyrazolopyrimidines from Aromatic Aldehydes, Meldrum's Acid, and Aminopyrazole CAN508

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About: Multicomponent and Regioselective Synthesis of Dihydropyrazolopyrimidines from Aromatic Aldehydes, Meldrum's Acid, and Aminopyrazole CAN508 Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A regioselective synthesis of dihydropyrazolopyrimidines is reported. The multicomponent reaction of readily available arylaldehydes, Meldrum's acid, and aminopyrazole CAN508 afforded fused pyrazolopyrimidines in high yields. The reaction proceeded regioselectively via initial Michael addition of the exocyclic amino group to arylidene Meldrum's acid intermediate followed by a ring closure at the endocyclic nitrogen of aminopyrazole. The regioselectivity of the reaction was determined by X-ray crystallography. A regioselective synthesis of dihydropyrazolopyrimidines is reported. The multicomponent reaction of readily available arylaldehydes, Meldrum's acid, and aminopyrazole CAN508 afforded fused pyrazolopyrimidines in high yields. The reaction proceeded regioselectively via initial Michael addition of the exocyclic amino group to arylidene Meldrum's acid intermediate followed by a ring closure at the endocyclic nitrogen of aminopyrazole. The regioselectivity of the reaction was determined by X-ray crystallography. (en)
Title	Multicomponent and Regioselective Synthesis of Dihydropyrazolopyrimidines from Aromatic Aldehydes, Meldrum's Acid, and Aminopyrazole CAN508 Multicomponent and Regioselective Synthesis of Dihydropyrazolopyrimidines from Aromatic Aldehydes, Meldrum's Acid, and Aminopyrazole CAN508 (en)
skos:prefLabel	Multicomponent and Regioselective Synthesis of Dihydropyrazolopyrimidines from Aromatic Aldehydes, Meldrum's Acid, and Aminopyrazole CAN508 Multicomponent and Regioselective Synthesis of Dihydropyrazolopyrimidines from Aromatic Aldehydes, Meldrum's Acid, and Aminopyrazole CAN508 (en)
skos:notation	RIV/61989592:15310/14:33151965!RIV15-MSM-15310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0058), P(EE2.3.20.0009), P(EE2.3.20.0017), P(EE2.4.31.0130), S
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Jedinák, Lukáš Kryštof, Vladimír Trávníček, Zdeněk Cankař, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	30946
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/14:33151965
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pyrazole, CDK, multicomponent reaction (en)
http://linked.open.../riv/klicoveSlovo	multicomponent reaction pyrazole CDK
http://linked.open...odStatuVydavatele	JP - Japonsko
http://linked.open...ontrolniKodProRIV	[63A283BC2F8E]
http://linked.open...i/riv/nazevZdroje	Heterocycles
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Development and bolstering of cooperation among academic and commercial institutions with focuse on chemical and pharmaceutical research Regional Centre of Advanced Technologies and Materials Research team development of the Regional Centre of Advanced Technologies and Materials Combinatorial chemistry in research and education
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	89
http://linked.open...iv/tvurceVysledku	Kryštof, Vladimír Trávníček, Zdeněk Cankař, Petr Jedinák, Lukáš
http://linked.open...ain/vavai/riv/wos	000342253700008
issn	0385-5414
number of pages	3 (xsd:int)
http://bibframe.org/vocab/doi	10.3987/COM-14-13026
http://localhost/t...ganizacniJednotka	15310

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