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  • This work rationalizes the glucuronidation process (one of the reactions of the phase II metabolism) for drugs having a carboxylic acid moiety. At this stage, acylglucuronides (AG) metabolites are produced, that have largely been reported in the literature for various drugs (e.g., mycophenolic acid (MPA), diclofenac, ibuprofen, phenylacetic acids). The competition between migration and hydrolysis is rationalized by adequate quantum calculations, combing MP2 and density functional theory (DFT) methods. At the molecular scale, the former process is a real rotation of the drug around the glucuconic acid. This chemical-engine provides four different metabolites with various toxicities. Migration definitely appears feasible under alkaline conditions, making proton release from the OH groups. The latter reaction (hydrolysis) releases the free drug, so the competition is of crucial importance to tackle drug action and elimination. From the theoretical data, both migration and hydrolysis appear kinetically and thermodynamically favored, respectively.
  • This work rationalizes the glucuronidation process (one of the reactions of the phase II metabolism) for drugs having a carboxylic acid moiety. At this stage, acylglucuronides (AG) metabolites are produced, that have largely been reported in the literature for various drugs (e.g., mycophenolic acid (MPA), diclofenac, ibuprofen, phenylacetic acids). The competition between migration and hydrolysis is rationalized by adequate quantum calculations, combing MP2 and density functional theory (DFT) methods. At the molecular scale, the former process is a real rotation of the drug around the glucuconic acid. This chemical-engine provides four different metabolites with various toxicities. Migration definitely appears feasible under alkaline conditions, making proton release from the OH groups. The latter reaction (hydrolysis) releases the free drug, so the competition is of crucial importance to tackle drug action and elimination. From the theoretical data, both migration and hydrolysis appear kinetically and thermodynamically favored, respectively. (en)
Title
  • Acylglucuronide in alkaline conditions: migration vs. hydrolysis
  • Acylglucuronide in alkaline conditions: migration vs. hydrolysis (en)
skos:prefLabel
  • Acylglucuronide in alkaline conditions: migration vs. hydrolysis
  • Acylglucuronide in alkaline conditions: migration vs. hydrolysis (en)
skos:notation
  • RIV/61989592:15310/13:33148490!RIV14-MSM-15310___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(ED2.1.00/03.0058)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
  • Trouillas, Patrick
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
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  • 59440
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  • RIV/61989592:15310/13:33148490
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  • Thermodynamics; Migration; Kinetics; DFT; Alkaline hydrolysis; Acylglucuronides (en)
http://linked.open.../riv/klicoveSlovo
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  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [84A6D5D699F2]
http://linked.open...i/riv/nazevZdroje
  • Journal of Molecular Modeling
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http://linked.open...vavai/riv/projekt
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  • 19
http://linked.open...iv/tvurceVysledku
  • Trouillas, Patrick
  • Di Meo, Florent
  • Duroux, Jean-Luc
  • Marquet, Pierre
  • Nicolas, Picard
  • Steel, Michele
http://linked.open...ain/vavai/riv/wos
  • 000319362500027
issn
  • 1610-2940
number of pages
http://bibframe.org/vocab/doi
  • 10.1007/s00894-013-1790-3
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  • 15310
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