About: Transcriptional Regulation of Human Drug-Metabolizing Cytochrome P450 Enzymes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Regulation of drug-metabolizing cytochromes P450 (CYPs) occurs via multiple mechanisms. A pivotal means of CYP regulation is transcriptional control, which influences the expression and the amount of the enzyme. Many xenobiotics, including therapeutically used drugs, upregulate (induce) the expression of CYPs by transcriptional mechanisms. Xenobiotic-mediated induction of CYPs results in altered intermediary metabolism as well as the metabolism of drugs and it is, hence, a serious cause of drug-drug interactions. The current chapter summarizes our knowledge on the transcriptional regulation of drug-inducible CYPs comprising CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2Cs, and CYP3A4 genes. The role of pregnane X receptor, constitutive androstane receptor, aryl hydrocarbon receptor, steroid receptors (glucocorticoid receptor, estrogen receptor), nuclear receptors (vitamin D receptor, retinoic X receptor, liver X receptor) and transcriptional factors (HNF-4, C/EBP, SMRT, etc.) is explained. Regulation of drug-metabolizing cytochromes P450 (CYPs) occurs via multiple mechanisms. A pivotal means of CYP regulation is transcriptional control, which influences the expression and the amount of the enzyme. Many xenobiotics, including therapeutically used drugs, upregulate (induce) the expression of CYPs by transcriptional mechanisms. Xenobiotic-mediated induction of CYPs results in altered intermediary metabolism as well as the metabolism of drugs and it is, hence, a serious cause of drug-drug interactions. The current chapter summarizes our knowledge on the transcriptional regulation of drug-inducible CYPs comprising CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2Cs, and CYP3A4 genes. The role of pregnane X receptor, constitutive androstane receptor, aryl hydrocarbon receptor, steroid receptors (glucocorticoid receptor, estrogen receptor), nuclear receptors (vitamin D receptor, retinoic X receptor, liver X receptor) and transcriptional factors (HNF-4, C/EBP, SMRT, etc.) is explained. (en)
Title	Transcriptional Regulation of Human Drug-Metabolizing Cytochrome P450 Enzymes Transcriptional Regulation of Human Drug-Metabolizing Cytochrome P450 Enzymes (en)
skos:prefLabel	Transcriptional Regulation of Human Drug-Metabolizing Cytochrome P450 Enzymes Transcriptional Regulation of Human Drug-Metabolizing Cytochrome P450 Enzymes (en)
skos:notation	RIV/61989592:15310/12:33142726!RIV13-GA0-15310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP304/10/0149), P(GAP503/10/0579)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Dvořák, Zdeněk
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	174854
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/12:33142726
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytochrome P450, nuclear receptor, xenoreceptor, steroid receptor, induction, drug, metabolism (en)
http://linked.open.../riv/klicoveSlovo	xenoreceptor steroid receptor metabolism nuclear receptor cytochrome P450 drug induction
http://linked.open...ontrolniKodProRIV	[557FE20BB47C]
http://linked.open...i/riv/mistoVydani	Weinheim
http://linked.open...vEdiceCisloSvazku	Neuveden
http://linked.open...i/riv/nazevZdroje	Metabolism of Drugs and Other Xenobiotics
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...v/pocetStranKnihy	753 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Generation of hepatocyte-derived cellular models for preclinical testing of drugs Study of potential interaction of constituents of non-alcoholic beverages with signaling pathways involved in drug metabolism and carcinogenesis
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Dvořák, Zdeněk
number of pages	36 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Wiley-VCH Verlag
https://schema.org/isbn	978-3-527-32903-8
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	Transcriptional Regulation of Human Drug-Metabolizing Cytochrome P450 Enzymes

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