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  • Antabuse in the human body is metabolized to diethyldithiocarbamate and its derivatives,1 which are quite reactive compounds2 targeting many cellular proteins.3 However, the active compounds in Antabuse-mediated cancer suppression seem to be relatively nonreactive complexes of diethyldithiocarbamate with zinc or copper formed in the body, not Antabuse on its own. That is why Antabuse is tested with copper supplementation in Utah clinical trial (ClinicalTrials.gov Identifier: NCT00742911).
  • Antabuse in the human body is metabolized to diethyldithiocarbamate and its derivatives,1 which are quite reactive compounds2 targeting many cellular proteins.3 However, the active compounds in Antabuse-mediated cancer suppression seem to be relatively nonreactive complexes of diethyldithiocarbamate with zinc or copper formed in the body, not Antabuse on its own. That is why Antabuse is tested with copper supplementation in Utah clinical trial (ClinicalTrials.gov Identifier: NCT00742911). (en)
Title
  • Antabuse repurposing: we need more knowledge and wide international support
  • Antabuse repurposing: we need more knowledge and wide international support (en)
skos:prefLabel
  • Antabuse repurposing: we need more knowledge and wide international support
  • Antabuse repurposing: we need more knowledge and wide international support (en)
skos:notation
  • RIV/61989592:15310/11:33118863!RIV12-GA0-15310___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP303/08/P137)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 186369
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15310/11:33118863
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • COMPLEXES; DISULFIRAM; PROTEASOME (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [FE23A6CB3EBD]
http://linked.open...i/riv/nazevZdroje
  • International Journal of Cancer (print)
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 129
http://linked.open...iv/tvurceVysledku
  • Cvek, Boris
http://linked.open...ain/vavai/riv/wos
  • 000292509400028
issn
  • 0020-7136
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/ijc.25779
http://localhost/t...ganizacniJednotka
  • 15310
is http://linked.open...avai/riv/vysledek of
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