About: Determination of rosiglitazone and metformin in human serum by CE-ESI-MS

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A new method for the determination of anti-diabetic drugs metformin and rosiglitazone based on the use of capillary electrophoresis with electrospray mass spectrometry was developed. The proposed method allowed their separation within 11 min by using 50mM formic acid at 120 kV. Positive electrospray ionization and selected ion monitoring [M1H]1 of metformin (m/z5130) and rosiglitazone (m/z5358) were performed. Several important experimental parameters influencing electrospray ionization of metformin and rosiglitazone were studied. The final composition of sheath liquid was water/methanol/formic acid (50:49.5:0.5, v/v/v), at a flow rate of 2 mL/min. The developed method was applied for the determination of metformin and rosiglitazone simultaneously in human serum after protein precipitation with acetonitrile. The limits of detection of developed method were 4.42 and 2.14 ng/mL for rosiglitazone and for metformin, respectively, which is sufficient for therapeutic serum concentration levels monitoring for both studied drugs. A new method for the determination of anti-diabetic drugs metformin and rosiglitazone based on the use of capillary electrophoresis with electrospray mass spectrometry was developed. The proposed method allowed their separation within 11 min by using 50mM formic acid at 120 kV. Positive electrospray ionization and selected ion monitoring [M1H]1 of metformin (m/z5130) and rosiglitazone (m/z5358) were performed. Several important experimental parameters influencing electrospray ionization of metformin and rosiglitazone were studied. The final composition of sheath liquid was water/methanol/formic acid (50:49.5:0.5, v/v/v), at a flow rate of 2 mL/min. The developed method was applied for the determination of metformin and rosiglitazone simultaneously in human serum after protein precipitation with acetonitrile. The limits of detection of developed method were 4.42 and 2.14 ng/mL for rosiglitazone and for metformin, respectively, which is sufficient for therapeutic serum concentration levels monitoring for both studied drugs. (en)
Title	Determination of rosiglitazone and metformin in human serum by CE-ESI-MS Determination of rosiglitazone and metformin in human serum by CE-ESI-MS (en)
skos:prefLabel	Determination of rosiglitazone and metformin in human serum by CE-ESI-MS Determination of rosiglitazone and metformin in human serum by CE-ESI-MS (en)
skos:notation	RIV/61989592:15310/11:33117310!RIV12-MSM-15310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0058), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Maier, Vítězslav Ševčík, Juraj Ranc, Václav Znaleziona, Joanna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	193879
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/11:33117310
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Capillary electrophoresis, Electrospray, Mass spectrometry, Metformin, Rosiglitazone (en)
http://linked.open.../riv/klicoveSlovo	Capillary electrophoresis Mass spectrometry Electrospray Metformin Rosiglitazone
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[CA96ACFED056]
http://linked.open...i/riv/nazevZdroje	Journal of Separation Science
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Regional Centre of Advanced Technologies and Materials
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Maier, Vítězslav Ranc, Václav Znaleziona, Joanna Ševčík, Juraj
http://linked.open...ain/vavai/riv/wos	000290635400010
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1615-9306
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/jssc.201000823
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	Determination of rosiglitazone and metformin in human serum by CE-ESI-MS Determination of rosiglitazone and metformin in human serum by CE-ESI-MS

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