About: In vitro and in vivo biological activity screening of Ru(III) complexes involving 6-benzylaminopurine derivatives with higher pro-apoptotic activity than NAMI-A

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About: In vitro and in vivo biological activity screening of Ru(III) complexes involving 6-benzylaminopurine derivatives with higher pro-apoptotic activity than NAMI-A Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A series of novel octahedral ruthenium(III) complexes involving 6-benzylaminopurine (L) derivatives as N-donor ligands has been prepared by the reaction of [(DMSO)2H][trans-RuCl4(DMSO)2]with the corresponding L derivative. The complexes 1-12 have the general compositions trans-[RuCl4(DMSO)(n-Cl-LH)]?xSol (1-3), trans-[RuCl4(DMSO)(n-Br-LH)]?xSol (4-6), trans-[RuCl4(DMSO)(n-OMe-LH)]?xSol (7-9) and trans-[RuCl4(DMSO)(n-OHLH)]?xSol (10-12); n=2, 3, and 4, x=0-1.5; and Sol = H2O, DMSO, EtOH and/or (Me)2CO. The complexes have been thoroughly characterized by elemental analysis,UV-visible, FTIR, Raman, and EPR spectroscopy, ES+(positive ionization electrospray) mass spectrometry, thermal analysis, cyclic voltammetry, magnetic and conductivity measurements. A series of novel octahedral ruthenium(III) complexes involving 6-benzylaminopurine (L) derivatives as N-donor ligands has been prepared by the reaction of [(DMSO)2H][trans-RuCl4(DMSO)2]with the corresponding L derivative. The complexes 1-12 have the general compositions trans-[RuCl4(DMSO)(n-Cl-LH)]?xSol (1-3), trans-[RuCl4(DMSO)(n-Br-LH)]?xSol (4-6), trans-[RuCl4(DMSO)(n-OMe-LH)]?xSol (7-9) and trans-[RuCl4(DMSO)(n-OHLH)]?xSol (10-12); n=2, 3, and 4, x=0-1.5; and Sol = H2O, DMSO, EtOH and/or (Me)2CO. The complexes have been thoroughly characterized by elemental analysis,UV-visible, FTIR, Raman, and EPR spectroscopy, ES+(positive ionization electrospray) mass spectrometry, thermal analysis, cyclic voltammetry, magnetic and conductivity measurements. (en)
Title	In vitro and in vivo biological activity screening of Ru(III) complexes involving 6-benzylaminopurine derivatives with higher pro-apoptotic activity than NAMI-A In vitro and in vivo biological activity screening of Ru(III) complexes involving 6-benzylaminopurine derivatives with higher pro-apoptotic activity than NAMI-A (en)
skos:prefLabel	In vitro and in vivo biological activity screening of Ru(III) complexes involving 6-benzylaminopurine derivatives with higher pro-apoptotic activity than NAMI-A In vitro and in vivo biological activity screening of Ru(III) complexes involving 6-benzylaminopurine derivatives with higher pro-apoptotic activity than NAMI-A (en)
skos:notation	RIV/61989592:15310/11:10222344!RIV12-MSM-15310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0058), P(GP203/08/P436), S, Z(MSM6198959218)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Trávníček, Zdeněk Vančo, Ján Štěpánková, Kamila Novotná, Radka Matiková Mal'Arová, Miroslava
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	204029
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/11:10222344
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ruthenium(III) complexes, Purine derivatives, Crystal structure, Antiradical activity, In vitro cytotoxicity, In vivo antitumor activity (en)
http://linked.open.../riv/klicoveSlovo	Antiradical activity In vitro cytotoxicity In vivo antitumor activity Purine derivatives Ruthenium(III) complexes Crystal structure
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[123815E1B5BC]
http://linked.open...i/riv/nazevZdroje	Journal of Inorganic Biochemistry
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Ru and Rh complexes with potential biological activity Regional Centre of Advanced Technologies and Materials
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	105
http://linked.open...iv/tvurceVysledku	Suchý, Pavel Trávníček, Zdeněk Matiková Mal'Arová, Miroslava Novotná, Radka Vančo, Ján Štěpánková, Kamila
http://linked.open...ain/vavai/riv/wos	000291518700002
http://linked.open...n/vavai/riv/zamer	Komplexní sloučeniny a oxidy přechodných kovů s využitím v bioaplikacích a nanotechnologiích
issn	0162-0134
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jinorgbio.2011.04.002
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	In vitro and in vivo biological activity screening of Ru(III) complexes involving 6-benzylaminopurine derivatives with higher pro-apoptotic activity than NAMI-A In vitro and in vivo biological activity screening of Ru(III) complexes involving 6-benzylaminopurine derivatives with higher pro-apoptotic activity than NAMI-A

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