About: The BDNF Val66Met polymorphism is not associated with myocardial infarction in Czech patients.

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About: The BDNF Val66Met polymorphism is not associated with myocardial infarction in Czech patients. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of coronary artery disease (CAD). BDNF Val66Met polymorphism has recently been associated with particular manifestation of CAD (unstable angina) in Chinese population. To further explore a possible role of this polymorphism as a genetic modifier in CAD we have investigated its association with myocardial infarction in the Czech population. BDNF Val66Met polymorphism was genotyped by realtime PCR (TaqMan) in 180 healthy unrelated control subjects and in 217 patients with myocardial infarction (MI) diagnosed according to the international (ESC) consensus. Genotype and allele frequencies of the BDNF Val66Met polymorphism did not differ between MI patients (frequency of BDNF 66Met allele: 18%, Met/Met genotype 4%) and control subjects (17%, 5%, p}0.05). Similarly, no association of BDNF Val66Met variant with MI was observed in the subanalysis according to the gender. Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of coronary artery disease (CAD). BDNF Val66Met polymorphism has recently been associated with particular manifestation of CAD (unstable angina) in Chinese population. To further explore a possible role of this polymorphism as a genetic modifier in CAD we have investigated its association with myocardial infarction in the Czech population. BDNF Val66Met polymorphism was genotyped by realtime PCR (TaqMan) in 180 healthy unrelated control subjects and in 217 patients with myocardial infarction (MI) diagnosed according to the international (ESC) consensus. Genotype and allele frequencies of the BDNF Val66Met polymorphism did not differ between MI patients (frequency of BDNF 66Met allele: 18%, Met/Met genotype 4%) and control subjects (17%, 5%, p}0.05). Similarly, no association of BDNF Val66Met variant with MI was observed in the subanalysis according to the gender. (en)
Title	The BDNF Val66Met polymorphism is not associated with myocardial infarction in Czech patients. The BDNF Val66Met polymorphism is not associated with myocardial infarction in Czech patients. (en)
skos:prefLabel	The BDNF Val66Met polymorphism is not associated with myocardial infarction in Czech patients. The BDNF Val66Met polymorphism is not associated with myocardial infarction in Czech patients. (en)
skos:notation	RIV/61989592:15310/11:10222091!RIV12-MSM-15310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(ME 856), S, Z(MSM6198959205)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Motáková, Natálie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	187913
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/11:10222091
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	single nucleotide polymorphism; brain-derived neurotrophic factor (BDNF); neurotrophins; atherosclerosis; coronary artery disease (en)
http://linked.open.../riv/klicoveSlovo	brain-derived neurotrophic factor (BDNF) coronary artery disease neurotrophins single nucleotide polymorphism atherosclerosis
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[487C8DD7A0A6]
http://linked.open...i/riv/nazevZdroje	Cytokine
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20856
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Motáková, Natálie Mrázek, František Petřek, Martin Petřková, Jana Sťahelová, Anna Táborský, Miloš
http://linked.open...n/vavai/riv/zamer	Studies of genes and molecular mechanisms involved in regulation of hematopoiesis, their clinical impact and targeted treatment
issn	1043-4666
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	The BDNF Val66Met polymorphism is not associated with myocardial infarction in Czech patients. The BDNF Val66Met polymorphism is not associated with myocardial infarction in Czech patients.

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