About: Electrochemical characterization of repaglinide and its determination in human plasma using liquid chromatography with dual-channel coulometric detection

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About: Electrochemical characterization of repaglinide and its determination in human plasma using liquid chromatography with dual-channel coulometric detection Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A simple fast and sensitive HPLC method employing dual-channel coulometric detection for the determination of repaglinide in human plasma is presented The assay involved extraction of repaglinide by ethyl acetate and isocratic reversed-phase liquid chromatography with dual-channel coulometric detection The mobile phase composition was 50mM disodium hydrogen phosphate/acetonitrile (60 40 v/v) pH of the mobile phase 7 5 set up with phosphoric acid For all analyses the first cell working potential was +380 mV the second was +750 mV (vs Pd/H-2) Calibration curve was linear over the concentration range of 5-500 nmol L-1 Rosiglitazone was used as an internal standard The limit of detection CLOD) was established at 28 nmol L-1 and the lower limit of quantification (LLOQ) at 85 nmol L-1 The developed method was applied to human plasma samples spiked with repaglinide at therapeutical concentrations It was confirmed that the method is suitable for pharmacokinetic studies or therapeutic monitoring A simple fast and sensitive HPLC method employing dual-channel coulometric detection for the determination of repaglinide in human plasma is presented The assay involved extraction of repaglinide by ethyl acetate and isocratic reversed-phase liquid chromatography with dual-channel coulometric detection The mobile phase composition was 50mM disodium hydrogen phosphate/acetonitrile (60 40 v/v) pH of the mobile phase 7 5 set up with phosphoric acid For all analyses the first cell working potential was +380 mV the second was +750 mV (vs Pd/H-2) Calibration curve was linear over the concentration range of 5-500 nmol L-1 Rosiglitazone was used as an internal standard The limit of detection CLOD) was established at 28 nmol L-1 and the lower limit of quantification (LLOQ) at 85 nmol L-1 The developed method was applied to human plasma samples spiked with repaglinide at therapeutical concentrations It was confirmed that the method is suitable for pharmacokinetic studies or therapeutic monitoring (en)
Title	Electrochemical characterization of repaglinide and its determination in human plasma using liquid chromatography with dual-channel coulometric detection Electrochemical characterization of repaglinide and its determination in human plasma using liquid chromatography with dual-channel coulometric detection (en)
skos:prefLabel	Electrochemical characterization of repaglinide and its determination in human plasma using liquid chromatography with dual-channel coulometric detection Electrochemical characterization of repaglinide and its determination in human plasma using liquid chromatography with dual-channel coulometric detection (en)
skos:notation	RIV/61989592:15310/10:10215670!RIV11-MSM-15310___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	31
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Skopalová, Jana Maier, Vítězslav Jirovský, David Bartošová, Zdenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	256699
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/10:10215670
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Plasma; Peroral antidiabetics; Coulometric detection; HPLC; Rosiglitazone; Repaglinide (en)
http://linked.open.../riv/klicoveSlovo	Peroral antidiabetics Repaglinide Rosiglitazone HPLC Plasma Coulometric detection
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[70FAB3C67D18]
http://linked.open...i/riv/nazevZdroje	Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	878
http://linked.open...iv/tvurceVysledku	Skopalová, Jana Maier, Vítězslav Bartošová, Zdenka Jirovský, David
http://linked.open...ain/vavai/riv/wos	000285118100006
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1570-0232
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	Electrochemical characterization of repaglinide and its determination in human plasma using liquid chromatography with dual-channel coulometric detection Electrochemical characterization of repaglinide and its determination in human plasma using liquid chromatography with dual-channel coulometric detection Electrochemical characterization of repaglinide and its determination in human plasma using liquid chromatography with dual-channel coulometric detection

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