About: Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant     Goto   Sponge   NotDistinct   Permalink

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  • A method for the separation of six selected antihyperglycemic (antidiabetic) drugs (tolbutamide, gliclazide, glimepiride, glibenclamide, repaglinide, and glipizide) was developed with use of micellar electrokinetic chromatography. Two non-ionic poly(ethylene glycol)-based surfactants Genapol X-080 and Triton X-114 (reduced) were studied as neutral pseudostationary phases. High alkaline pH 10.0 was used to obtain negative charges of separated antidiabetic drugs and non-ionic surfactants were employed for selectivity alteration. Both non-ionic surfactants provided good selectivity at concentration 0.2% (v/v) in sodium borate buffer and the separation of six drugs was obtained within 5 min. An on-line preconcentration method based on reversed electrode polarity switching was employed for the determination of anti hyperglycemic drugs in blood serum after acetonitrile protein precipitation. The limits of detection ranged from 20.8 nmol L-(1) for tolbutamide to 6.5 nmol L-1 for glibenclamide, respectively.
  • A method for the separation of six selected antihyperglycemic (antidiabetic) drugs (tolbutamide, gliclazide, glimepiride, glibenclamide, repaglinide, and glipizide) was developed with use of micellar electrokinetic chromatography. Two non-ionic poly(ethylene glycol)-based surfactants Genapol X-080 and Triton X-114 (reduced) were studied as neutral pseudostationary phases. High alkaline pH 10.0 was used to obtain negative charges of separated antidiabetic drugs and non-ionic surfactants were employed for selectivity alteration. Both non-ionic surfactants provided good selectivity at concentration 0.2% (v/v) in sodium borate buffer and the separation of six drugs was obtained within 5 min. An on-line preconcentration method based on reversed electrode polarity switching was employed for the determination of anti hyperglycemic drugs in blood serum after acetonitrile protein precipitation. The limits of detection ranged from 20.8 nmol L-(1) for tolbutamide to 6.5 nmol L-1 for glibenclamide, respectively. (en)
Title
  • Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant
  • Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant (en)
skos:prefLabel
  • Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant
  • Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant (en)
skos:notation
  • RIV/61989592:15310/09:00010414!RIV10-MSM-15310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP203/07/P223), S, Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika
  • 20
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...dnocenehoVysledku
  • 309877
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15310/09:00010414
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Micellar electrokinetic chromatography; Antihyperglycemic drug; Antidiabetic drug; Gliclazide; Glibenclamide; Glimepiride; Glipizide; Repaglinide; Tolbutamide; Non-ionic surfactant; Genapol X-080; Triton X-114 (reduced); On-line preconcentration (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [53306B245F9B]
http://linked.open...i/riv/nazevZdroje
  • Journal of Chromatography A: Symposium Volumes
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 1216
http://linked.open...iv/tvurceVysledku
  • Petr, Jan
  • Skopalová, Jana
  • Maier, Vítězslav
  • Znaleziona, Joanna
  • Ševčík, Juraj
  • Jirovský, David
http://linked.open...n/vavai/riv/zamer
issn
  • 0021-9673
number of pages
http://localhost/t...ganizacniJednotka
  • 15310
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