About: Two C-terminal ankyrin repeats form the minimal stable unit of the ankyrin repeat protein p18INK4c

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About: Two C-terminal ankyrin repeats form the minimal stable unit of the ankyrin repeat protein p18INK4c Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ve studii jsou prezentovány MD simulace na celkové škále 450 ns různě velkých fragmentů proteinu p18INK4c. (cs) Ankyrin repeat proteins (ARPs) appear to be abundant in organisms from all phyla, and play critical regulatory roles, mediating specific interactions with target biomolecules and thus ordering the sequence of events in diverse cellular processes. ARPs possess a non-globular scaffold consisting of repeating motifs named ankyrin (ANK) repeats, which stack on each other. The modular architecture of ARPs provides a new paradigm for understanding protein stability and folding mechanisms. In the present study, the stability of various C-terminal fragments of the ARP p18(INK4c) was investigated by all-atomic 450 ns molecular dynamics (MD) simulations in explicit water solvent. Only motifs with at least two ANK repeats made stable systems in the available timescale. All smaller fragments were unstable, readily losing their native fold and alpha-helical content. Since each non-terminal ANK repeat has two hydrophobic sides, we may hypothesize that at least one hydrophobic side must be fully covered and shielded Ankyrin repeat proteins (ARPs) appear to be abundant in organisms from all phyla, and play critical regulatory roles, mediating specific interactions with target biomolecules and thus ordering the sequence of events in diverse cellular processes. ARPs possess a non-globular scaffold consisting of repeating motifs named ankyrin (ANK) repeats, which stack on each other. The modular architecture of ARPs provides a new paradigm for understanding protein stability and folding mechanisms. In the present study, the stability of various C-terminal fragments of the ARP p18(INK4c) was investigated by all-atomic 450 ns molecular dynamics (MD) simulations in explicit water solvent. Only motifs with at least two ANK repeats made stable systems in the available timescale. All smaller fragments were unstable, readily losing their native fold and alpha-helical content. Since each non-terminal ANK repeat has two hydrophobic sides, we may hypothesize that at least one hydrophobic side must be fully covered and shielded (en)
Title	Two C-terminal ankyrin repeats form the minimal stable unit of the ankyrin repeat protein p18INK4c Two C-terminal ankyrin repeats form the minimal stable unit of the ankyrin repeat protein p18INK4c (en) Dva C-terminální ankyrinové motivy tvoří minimální stabilní jednotku proteinu p18INK4c (cs)
skos:prefLabel	Two C-terminal ankyrin repeats form the minimal stable unit of the ankyrin repeat protein p18INK4c Two C-terminal ankyrin repeats form the minimal stable unit of the ankyrin repeat protein p18INK4c (en) Dva C-terminální ankyrinové motivy tvoří minimální stabilní jednotku proteinu p18INK4c (cs)
skos:notation	RIV/61989592:15310/08:00005479!RIV09-MSM-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC512), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Otyepka, Michal Banáš, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	400938
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/08:00005479
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ankyrin repeat; p18INK4c; Minimal stable unit; Fragmentation; Molecular dynamics (en)
http://linked.open.../riv/klicoveSlovo	Molecular dynamics Ankyrin repeat Minimal stable unit p18INK4c Fragmentation
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[6CDD73EBA176]
http://linked.open...i/riv/nazevZdroje	Journal of Molecular Modeling
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for biomolecules and complex molecular systems
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Otyepka, Michal Banáš, Pavel Sklenovský, Petr
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1610-2940
number of pages	13 (xsd:int)
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	Two C-terminal ankyrin repeats form the minimal stable unit of the ankyrin repeat protein p18INK4c Two C-terminal ankyrin repeats form the minimal stable unit of the ankyrin repeat protein p18INK4c Two C-terminal ankyrin repeats form the minimal stable unit of the ankyrin repeat protein p18INK4c Two C-terminal ankyrin repeats form the minimal stable unit of the ankyrin repeat protein p18INK4c

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