About: Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Práce identifikuje flexibilní regiony lidské CDK2, uvádí jejich biologickou roli a evoluční konzervaci mezi CMGC kinasami. (cs) Cyclin-dependent kinase 2 (CDK2) is the most thoroughly studied of the cyclin-dependent kinases that regulate essential cellular processes, including the cell cycle, and it has become a model for studies of regulatory mechanisms at the molecular level. This contribution identifies flexible and rigid regions of CDK2 based on temperature B-factors acquired from both X-ray data and molecular dynamics simulations. In addition, the biological relevance of the identified flexible regions and their motions is explored using information from the essential dynamics analysis related to conformational changes of CDK2 and knowledge of its biological function(s). The conserved regions of CMGC protein kinases' primary sequences are located in the most rigid regions identified in our analyses, with the sole exception of the absolutely conserved G13 in the tip of the glycine-rich loop. The conserved rigid regions are important for nucleotide binding, catalysis, and substrate recognition. In contrast, the most fl Cyclin-dependent kinase 2 (CDK2) is the most thoroughly studied of the cyclin-dependent kinases that regulate essential cellular processes, including the cell cycle, and it has become a model for studies of regulatory mechanisms at the molecular level. This contribution identifies flexible and rigid regions of CDK2 based on temperature B-factors acquired from both X-ray data and molecular dynamics simulations. In addition, the biological relevance of the identified flexible regions and their motions is explored using information from the essential dynamics analysis related to conformational changes of CDK2 and knowledge of its biological function(s). The conserved regions of CMGC protein kinases' primary sequences are located in the most rigid regions identified in our analyses, with the sole exception of the absolutely conserved G13 in the tip of the glycine-rich loop. The conserved rigid regions are important for nucleotide binding, catalysis, and substrate recognition. In contrast, the most fl (en)
Title	Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation Funkční flexibilita lidské cyklin-dependentní kinasy-2 její evoluční konzervace (cs) Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation (en)
skos:prefLabel	Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation Funkční flexibilita lidské cyklin-dependentní kinasy-2 její evoluční konzervace (cs) Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation (en)
skos:notation	RIV/61989592:15310/08:00005478!RIV09-MSM-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC512), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Bártová, Iveta Otyepka, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	368684
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/08:00005478
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	protein; dynamics; evolutionary conservation; cell cycle; protein kinase (en)
http://linked.open.../riv/klicoveSlovo	protein dynamics cell cycle protein kinase evolutionary conservation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[01A329CD6929]
http://linked.open...i/riv/nazevZdroje	Protein Science
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for biomolecules and complex molecular systems
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Koča, Jaroslav Otyepka, Michal Bártová, Iveta
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0961-8368
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation

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