About: The toxicity and pharmacokinetics of dihydrosanguinarine in rat: A pilot study.     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • The quaternary benzo[c]phenanthridine alkaloid sanguinarine (SG) is the main component of Sangrovit, a natural livestock feed additive. Dihydrosanguinarine (DHSG) has recently been identified as a SG metabolite in rat. The conversion of SG to DHSG is a likely elimination pathway of SG in mammals. This study was conducted to evaluate the toxicity of DHSG in male Wistar rats at concentrations of 100 and 500 ppm DHSG in feed for 90 days (average doses of 14 and 58 mg DHSG/kg body weight/day). No significant alterations in body or organ weights, macroscopic details of organs, histopathology of liver, ileum, kidneys, tongue, heart or gingiva, clinical chemistry or hematology markers in blood in the DHSG-treated animals were found compared to controls. No lymphocyte DNA damage by Comet assay, formation of DNA adducts in liver by 32P-postlabeling, modulation of cytochrome P450 1A1/2 or changes in oxidative stress parameters were found. Thus, repeated dosing of DHSG for 90 days at up to 500 ppm in t
  • The quaternary benzo[c]phenanthridine alkaloid sanguinarine (SG) is the main component of Sangrovit, a natural livestock feed additive. Dihydrosanguinarine (DHSG) has recently been identified as a SG metabolite in rat. The conversion of SG to DHSG is a likely elimination pathway of SG in mammals. This study was conducted to evaluate the toxicity of DHSG in male Wistar rats at concentrations of 100 and 500 ppm DHSG in feed for 90 days (average doses of 14 and 58 mg DHSG/kg body weight/day). No significant alterations in body or organ weights, macroscopic details of organs, histopathology of liver, ileum, kidneys, tongue, heart or gingiva, clinical chemistry or hematology markers in blood in the DHSG-treated animals were found compared to controls. No lymphocyte DNA damage by Comet assay, formation of DNA adducts in liver by 32P-postlabeling, modulation of cytochrome P450 1A1/2 or changes in oxidative stress parameters were found. Thus, repeated dosing of DHSG for 90 days at up to 500 ppm in t (en)
  • Kvartérní benzo[c]fenanthridinový alkaloid sanguinarin (SG) je hlavní složkou Sangrovitu, přídavku do krmiva pro dobytek. Dihydrosanguinarin (DHSG) byl recentně identifikován jako metabolit SG u potkana. Přeměna SG na DHSG je pravděpodobně eliminační dráha SG u savců. Tato studie byla prováděna s cílem hodnotit toxicitu DHSG u potkaních samců kmene Wistar rats krmených 90 dní 100 a 500 ppm DHSG (průměrné dávky 14 a 58 mg DHSG/kg tělesné hmotnosti/den). Ve srovnání s kontrolní skupinou nebyly u zvířat krmených DHSG zaznamenány změny v tělesné hmotnosti a hmotnosti orgánů, makroskopických detailech orgánů, histopatologii jater, ilea, ledvin, jazyka, srdce nebo gingivy a klinicko biochemických markerů v krvi. Nebylo nalezeno žádné poškození DNA v lymfocytech pomocí Comet assay, tvorba DNA duktů v játrech pomocí 32P-postlabeling, modulace cytochromu P450 1A1/2 nebo změny v parametrech oxidačního stresu. Tedy opakované dávkování DHSG po 90 dní v koncentracích do 500 ppm v potravě (i.e. cca 58 mg/kg/den) ne (cs)
Title
  • The toxicity and pharmacokinetics of dihydrosanguinarine in rat: A pilot study.
  • The toxicity and pharmacokinetics of dihydrosanguinarine in rat: A pilot study. (en)
  • Toxicita a farmakokinetika dihydrosanguinarinu u potkana: Pilotní studie. (cs)
skos:prefLabel
  • The toxicity and pharmacokinetics of dihydrosanguinarine in rat: A pilot study.
  • The toxicity and pharmacokinetics of dihydrosanguinarine in rat: A pilot study. (en)
  • Toxicita a farmakokinetika dihydrosanguinarinu u potkana: Pilotní studie. (cs)
skos:notation
  • RIV/61989592:15310/08:00005340!RIV09-MSM-15310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA525/07/0871), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 400297
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15310/08:00005340
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Benzo[c]phenanthridine alkaloid; Dihydrosanguinarine; Sanguinarine; Dietary toxicity; Metabolism; Disposition. (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [EBEC41A36182]
http://linked.open...i/riv/nazevZdroje
  • Food and Chemical Toxicology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 46
http://linked.open...iv/tvurceVysledku
  • Dvořák, Zdeněk
  • Kosina, Pavel
  • Stejskal, David
  • Ulrichová, Jitka
  • Vostálová, Jitka
  • Anzenbacher, Pavel
  • Klejdus, Bořivoj
  • Šimánek, Vilím
  • Večeřa, Rostislav
  • Vrublová, Eva
  • Svobodová, Alena
  • Vičar, Jaroslav
  • Lichnovský, Václav
  • Zdařilová, Adéla
http://linked.open...n/vavai/riv/zamer
issn
  • 0278-6915
number of pages
http://localhost/t...ganizacniJednotka
  • 15310
is http://linked.open...avai/riv/vysledek of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software