About: Active Sites of Cytochromes P450: What are They Like?

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ačkoliv X-ray krystalografie poskytuje cenné informace o struktuře, nemůže poskytnout úplné informace o flexibilitě aktivních míst. (cs) Although the x-ray crystallography is giving a relatively precise picture of spatial arrangement of the majority of protein structure, it is not able to give detailed information on the flexibility of the protein active site. The properties of active sites of cytochromes P450 (CYP) were supposed earlier to be relatively similar, reflecting the substrate specificities of the individual enzymes mainly by the amino acid residues present in the respective active site. On the other hand, the most recent experimental as well as theoretical results document that it is the flexibility of this part of protein which gives the active site the property to bind substrates correctly and to accommodate them. It is also the flexibility or plasticity of the structure which determines or limits the property of the protein to keep the conformation which guarantees the function of the enzyme. Although the x-ray crystallography is giving a relatively precise picture of spatial arrangement of the majority of protein structure, it is not able to give detailed information on the flexibility of the protein active site. The properties of active sites of cytochromes P450 (CYP) were supposed earlier to be relatively similar, reflecting the substrate specificities of the individual enzymes mainly by the amino acid residues present in the respective active site. On the other hand, the most recent experimental as well as theoretical results document that it is the flexibility of this part of protein which gives the active site the property to bind substrates correctly and to accommodate them. It is also the flexibility or plasticity of the structure which determines or limits the property of the protein to keep the conformation which guarantees the function of the enzyme. (en)
Title	Active Sites of Cytochromes P450: What are They Like? Aktivní místa cytochromů P450: Jak vypadají? (cs) Active Sites of Cytochromes P450: What are They Like? (en)
skos:prefLabel	Active Sites of Cytochromes P450: What are They Like? Aktivní místa cytochromů P450: Jak vypadají? (cs) Active Sites of Cytochromes P450: What are They Like? (en)
skos:notation	RIV/61989592:15310/08:00005286!RIV09-MSM-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP305/06/P139), P(OC 133), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	ANZENBACHER, Pavel Otyepka, Michal Anzenbacherová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	354812
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/08:00005286
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cytochromes P450; active sites; protein flexibility; protein compressibility; molecular dynamics (en)
http://linked.open.../riv/klicoveSlovo	Cytochromes P450 active sites molecular dynamics protein compressibility protein flexibility
http://linked.open...odStatuVydavatele	SI - Slovinská republika
http://linked.open...ontrolniKodProRIV	[421111B6894F]
http://linked.open...i/riv/nazevZdroje	Acta Chimica Slovenica
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20133 Flexibility, Solvation, and Drug Binding of Pharmacologically Active Enzymes Cytochromes P450
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Otyepka, Michal Anzenbacher, Pavel Anzenbacherová, Eva Lange, Reinhard Skopalík, Josef
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1318-0207
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	Active Sites of Cytochromes P450: What are They Like? Active Sites of Cytochromes P450: What are They Like? Active Sites of Cytochromes P450: What are They Like? Active Sites of Cytochromes P450: What are They Like?

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