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| Description
| - Adiponectin is involved in the regulation of glucose and fatty acid metabolism, influences whole-body insulin sensitivity and protects arterial walls against the development of atherosclerosis. Plasma adiponectin is decreased in obese, insulin-resistant and Type 2 diabetic patients. Adiponectin circulates in plasma as high-, medium- and low-molecular-weight ('mass') forms (HMW, MMW and LMW respectively). The HMW form is believed to be closely associated with insulin sensitivity. The aim of the present study was to investigate whether diet-induced changes in body weight and insulin sensitivity were associated with changes in the quantity of adiponectin multimeric complexes. A total of 20 overweight or obese women (age, 39.4+/-9.5 years; body mass index, 32.2+/-6.4 kg/m(2)) underwent 12 weeks of low caloric diet (600 kcal/day less than energy requirements; where 1 kcal is approximately 4.184 kJ). Plasma samples were drawn before and after the study for biochemical analysis and Western blot det
- Adiponectin is involved in the regulation of glucose and fatty acid metabolism, influences whole-body insulin sensitivity and protects arterial walls against the development of atherosclerosis. Plasma adiponectin is decreased in obese, insulin-resistant and Type 2 diabetic patients. Adiponectin circulates in plasma as high-, medium- and low-molecular-weight ('mass') forms (HMW, MMW and LMW respectively). The HMW form is believed to be closely associated with insulin sensitivity. The aim of the present study was to investigate whether diet-induced changes in body weight and insulin sensitivity were associated with changes in the quantity of adiponectin multimeric complexes. A total of 20 overweight or obese women (age, 39.4+/-9.5 years; body mass index, 32.2+/-6.4 kg/m(2)) underwent 12 weeks of low caloric diet (600 kcal/day less than energy requirements; where 1 kcal is approximately 4.184 kJ). Plasma samples were drawn before and after the study for biochemical analysis and Western blot det (en)
- Adiponektin se účastní regulace metabolismu glukosy a mastných kyselin, ovlivňuje citlivost vůči insulinu a chrání před atherosklerózou. Adiponektin v plazmě se snižuje při obezitě a u diabetes. Plazmový adiponektin se vyskytuje ve formě oligomerních forem. Cílem studie bylo popsat, zda změny v tělesné váze citlivosti k insulinu jsou spojeny se změnami v zastoupení oligomerních forem adiponektinu. Vzorek pacientů (20), žen s obesitou či nadváhou, byl podroben hypokalorické dietě v délce 12 týdnů. Po skončení diety byl zjištěn výrazný úbytek nadváhy doprovázený zvýšením adiponektinu v plazmě a zvýšenou citlivostí k insulinu. Zvýšeny byly všechny formy adiponektinu tj. HMW, MMW a LMW, přičemž nebyla zjištěna korelace mezi nárůstem koncentrace adiponektinu a zvýšenou citlivostí k insulinu. (cs)
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| Title
| - An increase in plasma adiponectin multimeric complexes follows hypocaloric diet-induced weight loss in obese and overweight pre-menopausal women.
- An increase in plasma adiponectin multimeric complexes follows hypocaloric diet-induced weight loss in obese and overweight pre-menopausal women. (en)
- Zvýšení koncentrace multimerních komplexů adiponektinu v krevní plazmě odráží snížení váhy indukované hypokalorickou dietou u obézních žen a žen s nadváhou před menopauzou (cs)
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| skos:prefLabel
| - An increase in plasma adiponectin multimeric complexes follows hypocaloric diet-induced weight loss in obese and overweight pre-menopausal women.
- An increase in plasma adiponectin multimeric complexes follows hypocaloric diet-induced weight loss in obese and overweight pre-menopausal women. (en)
- Zvýšení koncentrace multimerních komplexů adiponektinu v krevní plazmě odráží snížení váhy indukované hypokalorickou dietou u obézních žen a žen s nadváhou před menopauzou (cs)
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| skos:notation
| - RIV/61989592:15310/07:00004715!RIV08-MSM-15310___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15310/07:00004715
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - adiponectin; adipose tissue; dietary intervention; insulin resistance; multimeric complex; obesity; weight loss (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kováčová, Zuzana
- Polák, Jan
- Samcová, Eva
- Šebela, Marek
- Štich, Vladimír
- Klimčáková, Eva
- Kováčiková, Michaela
- Vítková, Michaela
- Kuda, Ondřej
- Jacek, Martin
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| http://linked.open...n/vavai/riv/zamer
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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