About: 6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine-1,7-diium bis(perchlorate) monohydrate

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About: 6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine-1,7-diium bis(perchlorate) monohydrate Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://journals.iucr.org/e/issues/2004/12/00/issconts.html
Description	Byl studován chloristan 6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurin-1,7-diia monohydrát. (cs) The title compound, C15H20N6O2+.2ClO(4)(-).H2O, belongs to a group of cytokinin-derived compounds. It has been found that some cytokinin derivates, e. g. 2,6,9-trisubstituted purine derivates, behave as potent inhibitors of cyclin-dependent kinases (CDKs) and show anticancer activity. Olomoucine, i. e. the title cation in its neutral form, represents one of the first CDK specific inhibitors that selectively blocks CDK1, CDK2 and CDK5 kinases at micromolar concentrations. The asymmetric unit of the title compound consists of the diprotonated cation, two perchlorate anions and a water molecule of crystallization. The cation contains nearly planar benzene and purine ring systems, the dihedral angle between them being 46.77(6) degrees. The crystal strucure is stabilized by N-purine - H ... O-water/O-hydroxy, N-amine - H ... O-water/O-hydroxy, O-water - H ... O-perchlorate and O-hydroxy - H ... O-perchlorate hydrogen bonds. The title compound, C15H20N6O2+.2ClO(4)(-).H2O, belongs to a group of cytokinin-derived compounds. It has been found that some cytokinin derivates, e. g. 2,6,9-trisubstituted purine derivates, behave as potent inhibitors of cyclin-dependent kinases (CDKs) and show anticancer activity. Olomoucine, i. e. the title cation in its neutral form, represents one of the first CDK specific inhibitors that selectively blocks CDK1, CDK2 and CDK5 kinases at micromolar concentrations. The asymmetric unit of the title compound consists of the diprotonated cation, two perchlorate anions and a water molecule of crystallization. The cation contains nearly planar benzene and purine ring systems, the dihedral angle between them being 46.77(6) degrees. The crystal strucure is stabilized by N-purine - H ... O-water/O-hydroxy, N-amine - H ... O-water/O-hydroxy, O-water - H ... O-perchlorate and O-hydroxy - H ... O-perchlorate hydrogen bonds. (en)
Title	6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine-1,7-diium bis(perchlorate) monohydrate Chloristan 6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurin-1,7-diia monohydrát (cs) 6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine-1,7-diium bis(perchlorate) monohydrate (en)
skos:prefLabel	6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine-1,7-diium bis(perchlorate) monohydrate Chloristan 6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurin-1,7-diia monohydrát (cs) 6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine-1,7-diium bis(perchlorate) monohydrate (en)
skos:notation	RIV/61989592:15310/04:00002290!RIV/2005/MSM/153105/N
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 153100007)
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Kryštof, Vladimír Trávníček, Zdeněk
http://linked.open.../riv/druhVysledku	A(V) - Audiovizuální tvorba se vzdáleným přístupem
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	596728
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/04:00002290
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cyclin-dependent kinases;X-ray structure;crystal structures;roscovitine;inhibitor;complexes, olomoucine, purines, analogs, potent (en)
http://linked.open.../riv/klicoveSlovo	crystal structures analogs X-ray structure complexes roscovitine purines potent olomoucine inhibitor cyclin-dependent kinases
http://linked.open...i/riv/kodPristupu	V
http://linked.open...ontrolniKodProRIV	[69110E7BF325]
http://linked.open...i/riv/mistoVydani	Neuveden
http://linked.open...telVyzkumneZpravy	Blackwell Munksgaard
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...iv/tvurceVysledku	Kryštof, Vladimír Trávníček, Zdeněk
http://linked.open...rzeVyzkumneZpravy	60
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20153100007
http://localhost/t...ganizacniJednotka	15310

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