About: Interaction of pent-2-yne-1,5-diamine with plant copper amine oxidases

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About: Interaction of pent-2-yne-1,5-diamine with plant copper amine oxidases Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Plant copper-containing amine oxidases (EC 1.4.3.6) catalyze the oxidative deamination of biogenic amines, which are known as cellular regulators, to form the corresponding aldehydes, ammonia and hydrogen peroxide. The enzymes are dimeric proteins containing both cupric ion and topaquinone as cofactors in each of the two subunits. They have been localized in the cell wall. Thus their physiological role, except for that in the catabolism of amines, may be seen in connection with the production of hydrogen peroxide that is utilized in peroxidase-mediated reactions in this cell compartment1. Here we report a study on the reaction of grass pea (Lathyrus sativus, GPAO) and sainfoin (Onobrychis viciifolia, OVAO) amine oxidases with pent-2-yne-1,5-diamine (DAPY). DAPY reacted with the topaquinone cofactor and was only weakly oxidized. Prolonged incubations, however, resulted in irreversible inhibition of the enzymes. For GPAO and OVAO, the rates of inactivation of 0.1-0.3 min-1 were determined, the apparent Plant copper-containing amine oxidases (EC 1.4.3.6) catalyze the oxidative deamination of biogenic amines, which are known as cellular regulators, to form the corresponding aldehydes, ammonia and hydrogen peroxide. The enzymes are dimeric proteins containing both cupric ion and topaquinone as cofactors in each of the two subunits. They have been localized in the cell wall. Thus their physiological role, except for that in the catabolism of amines, may be seen in connection with the production of hydrogen peroxide that is utilized in peroxidase-mediated reactions in this cell compartment1. Here we report a study on the reaction of grass pea (Lathyrus sativus, GPAO) and sainfoin (Onobrychis viciifolia, OVAO) amine oxidases with pent-2-yne-1,5-diamine (DAPY). DAPY reacted with the topaquinone cofactor and was only weakly oxidized. Prolonged incubations, however, resulted in irreversible inhibition of the enzymes. For GPAO and OVAO, the rates of inactivation of 0.1-0.3 min-1 were determined, the apparent (en) Článek se zabývá interakcí pent-2-yn-1,5-diaminu s rostlinnými aminoxidasami obsahujícími měď. (cs)
Title	Interaction of pent-2-yne-1,5-diamine with plant copper amine oxidases Interaction of pent-2-yne-1,5-diamine with plant copper amine oxidases (en) Interakce pent-2-yn-1,5-diaminu s rostlinnými aminoxidasami obsahujícími měď (cs)
skos:prefLabel	Interaction of pent-2-yne-1,5-diamine with plant copper amine oxidases Interaction of pent-2-yne-1,5-diamine with plant copper amine oxidases (en) Interakce pent-2-yn-1,5-diaminu s rostlinnými aminoxidasami obsahujícími měď (cs)
skos:notation	RIV/61989592:15310/04:00002286!RIV/2005/MSM/153105/N
http://linked.open.../vavai/riv/strany	43-44
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 153100010)
http://linked.open...iv/cisloPeriodika	S
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Peč, Pavel Šebela, Marek Lemr, Karel Maloň, Michal Lenobel, René
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	568558
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/04:00002286
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	amine oxidase;diamine;mechanism-based inhibition;nuclear magnetic resonance;oxidation. (en)
http://linked.open.../riv/klicoveSlovo	amine oxidase oxidation. nuclear magnetic resonance mechanism-based inhibition diamine
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[583CD37EEA61]
http://linked.open...i/riv/nazevZdroje	Acta Universitatis Palackianae Olomucensis, Facultas Rerum Naturalium, Chemica
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Lemr, Karel Šebela, Marek Maloň, Michal Lenobel, René Havliš, Jan Peč, Pavel Lamplot, Zbyněk Sayre, Lawrence M.
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20153100010
issn	0232-0061
number of pages	275 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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