About: A molecular dynamics study of the cyclin-dependent kinase-2 (CDK2) with substrate peptide (HHASPRK) inhibition by phosphorylation

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About: A molecular dynamics study of the cyclin-dependent kinase-2 (CDK2) with substrate peptide (HHASPRK) inhibition by phosphorylation Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Je diskutována molekulová dynamika CDK2 se substrátovým peptidem HHASPRK a inhibice fosforylací. (cs) The cyclin-dependent kinase-2, CDK2, controls the eukaryotic cell cycle at the G1 -S boundary. CDK2 catalyzes the phosphoryl transfer of the adenosine-5´-triphosphate (ATP) ?-phosphate to serine or threonine hydroxyl in the protein substrate. The CDK2 activity is regulated by complex mechanism including binding to positive regulatorysubunit (Cyclin A or Cyclin E) and phosphorylation at positive regulatory site in the activation segment (T-loop)1. The CDK2 activity is inhibited in several ways, for example, by (de)phosphorylation, interaction with various artificial and natural protein inhibitors2,3, etc. The CDK2 can be also negatively regulated by phosphorylation at Y15 and, to a lesser extent, at T14 residue in the inhibition segment (G-loop)4. Mechanism of the CDK2 inhibition by phosphorylation is known from the kinetics experiments but the structural aspects of inhibition remains unclear. The first attempt to explain the mechanism of inhibition by phosphorylation came from molecular dynamics simul The cyclin-dependent kinase-2, CDK2, controls the eukaryotic cell cycle at the G1 -S boundary. CDK2 catalyzes the phosphoryl transfer of the adenosine-5´-triphosphate (ATP) ?-phosphate to serine or threonine hydroxyl in the protein substrate. The CDK2 activity is regulated by complex mechanism including binding to positive regulatorysubunit (Cyclin A or Cyclin E) and phosphorylation at positive regulatory site in the activation segment (T-loop)1. The CDK2 activity is inhibited in several ways, for example, by (de)phosphorylation, interaction with various artificial and natural protein inhibitors2,3, etc. The CDK2 can be also negatively regulated by phosphorylation at Y15 and, to a lesser extent, at T14 residue in the inhibition segment (G-loop)4. Mechanism of the CDK2 inhibition by phosphorylation is known from the kinetics experiments but the structural aspects of inhibition remains unclear. The first attempt to explain the mechanism of inhibition by phosphorylation came from molecular dynamics simul (en)
Title	A molecular dynamics study of the cyclin-dependent kinase-2 (CDK2) with substrate peptide (HHASPRK) inhibition by phosphorylation A molecular dynamics study of the cyclin-dependent kinase-2 (CDK2) with substrate peptide (HHASPRK) inhibition by phosphorylation (en) Molekulová dynamika CDK2 se substrátovým peptidem HHASPRK, inhibice fosforylací (cs)
skos:prefLabel	A molecular dynamics study of the cyclin-dependent kinase-2 (CDK2) with substrate peptide (HHASPRK) inhibition by phosphorylation A molecular dynamics study of the cyclin-dependent kinase-2 (CDK2) with substrate peptide (HHASPRK) inhibition by phosphorylation (en) Molekulová dynamika CDK2 se substrátovým peptidem HHASPRK, inhibice fosforylací (cs)
skos:notation	RIV/61989592:15310/04:00002046!RIV/2005/MSM/153105/N
http://linked.open.../vavai/riv/strany	260
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 153100007)
http://linked.open...iv/cisloPeriodika	Suppl.
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Otyepka, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	552986
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/04:00002046
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cyclic dependent kinase;CDK2;inhibition;phosphorylation (en)
http://linked.open.../riv/klicoveSlovo	CDK2 inhibition cyclic dependent kinase phosphorylation
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[00710A2DB1F7]
http://linked.open...i/riv/nazevZdroje	Acta Universitatis Palackianae Olomucensis, Facultas Rerum Naturalium, Chemica
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Koča, Jaroslav Otyepka, Michal Kříž, Zdeněk Bártová, Iveta
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20153100007
issn	0232-0061
number of pages	275 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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