About: Lessons from known P450 structures

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Lessons from known P450 structures Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	There is a considerable progress last five years in knowledge of the P450 (CYP) structures which allows to draw out at least some conclusions important for function of the respective enzymes. First, the structure of mammalian (rabbit) liver microsomal CYP2C5 was published in 2000 which allowed for detailed comparisons of all important human liver microsomal P450s. The next milestone was the structure of CYP2C9 presented in full in 2003 showing the first human liver microsomal P450 in the absence as well as in the presence of substrate. Third success was the resolution of the CYP3A4 structure presented this year. The structures show that although the overall %22P450 fold%22 is preserved, there are considerable differences in the ways the substrates approach the active site and in the properties of the active site itself. Relative flexibility and openness of the CYP3A4 active site was expected by the modeling as well as by the spectroscopic approaches. The CYP2C9 structure opens a possibility to study in mo There is a considerable progress last five years in knowledge of the P450 (CYP) structures which allows to draw out at least some conclusions important for function of the respective enzymes. First, the structure of mammalian (rabbit) liver microsomal CYP2C5 was published in 2000 which allowed for detailed comparisons of all important human liver microsomal P450s. The next milestone was the structure of CYP2C9 presented in full in 2003 showing the first human liver microsomal P450 in the absence as well as in the presence of substrate. Third success was the resolution of the CYP3A4 structure presented this year. The structures show that although the overall %22P450 fold%22 is preserved, there are considerable differences in the ways the substrates approach the active site and in the properties of the active site itself. Relative flexibility and openness of the CYP3A4 active site was expected by the modeling as well as by the spectroscopic approaches. The CYP2C9 structure opens a possibility to study in mo (en) Článek se zabývá známými strukturami cytochromu P450. (cs)
Title	Lessons from known P450 structures Lessons from known P450 structures (en) Známé struktury cytochromu P450 (cs)
skos:prefLabel	Lessons from known P450 structures Lessons from known P450 structures (en) Známé struktury cytochromu P450 (cs)
skos:notation	RIV/61989592:15310/04:00002037!RIV/2005/GA0/153105/N
http://linked.open.../vavai/riv/strany	198
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/99/0277), Z(MSM 153100007)
http://linked.open...iv/cisloPeriodika	Suppl.
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	ANZENBACHER, Pavel Otyepka, Michal Anzenbacherová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	571404
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/04:00002037
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytochromes;cytochrome P450;structures (en)
http://linked.open.../riv/klicoveSlovo	cytochromes structures cytochrome P450
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[802A7AC10D3C]
http://linked.open...i/riv/nazevZdroje	Acta Universitatis Palackianae Olomucensis, Facultas Rerum Naturalium, Chemica
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Cytochrome P450 3A - key enzyme of drug metabolism. Comparison of the human enzyme and of the model system
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Otyepka, Michal Anzenbacher, Pavel Anzenbacherová, Eva
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20153100007
issn	0232-0061
number of pages	275 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 35 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software