About: Recent news related to substrates and inhibitors of plant copper amine oxidases

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Plant copper amine oxidases (CAOs; EC 1.4.3.6) belong to the quinoprotein family. Besides the cofactor topaquinone, they also contain cupric ions participating in the reaction. Numerous substrates and inhibitors of plant CAOs have been reported up to date. We studied interactions of pea seedling enzyme (PSAO) with several artificial amine compounds that have not yet been analysed in this way and whose structure mimic natural polyamine substrates. In addition, our attention was paid to the evaluation of inhibition potency of sedamine alkaloids and various pyridine-derived oximes. 1,4-Bis(3-aminopropyl)piperazine, N,N´-bis(3-aminopropyl)-trans-2-butene-1,4-diamine and 3-oxapentane-1,5-diamine (OPD) were found to be substrates of PSAO. The corresponding enzyme kinetics was measured, the reaction stoichiometry analysed and rapid-scanning spectrophotometry applied to investigate the reaction mechanism. The identity of the main product of OPD conversion was confirmed by several analytical methods including Plant copper amine oxidases (CAOs; EC 1.4.3.6) belong to the quinoprotein family. Besides the cofactor topaquinone, they also contain cupric ions participating in the reaction. Numerous substrates and inhibitors of plant CAOs have been reported up to date. We studied interactions of pea seedling enzyme (PSAO) with several artificial amine compounds that have not yet been analysed in this way and whose structure mimic natural polyamine substrates. In addition, our attention was paid to the evaluation of inhibition potency of sedamine alkaloids and various pyridine-derived oximes. 1,4-Bis(3-aminopropyl)piperazine, N,N´-bis(3-aminopropyl)-trans-2-butene-1,4-diamine and 3-oxapentane-1,5-diamine (OPD) were found to be substrates of PSAO. The corresponding enzyme kinetics was measured, the reaction stoichiometry analysed and rapid-scanning spectrophotometry applied to investigate the reaction mechanism. The identity of the main product of OPD conversion was confirmed by several analytical methods including (en) Jsou prezentovány nejnovější poznatky o substrátech a inhibitorech rostlinných aminoxidas obsahujících měď. (cs)
Title	Recent news related to substrates and inhibitors of plant copper amine oxidases Recent news related to substrates and inhibitors of plant copper amine oxidases (en) Nejnovější poznatky o substrátech a inhibitorech rostlinných aminoxidas obsahujících měď (cs)
skos:prefLabel	Recent news related to substrates and inhibitors of plant copper amine oxidases Recent news related to substrates and inhibitors of plant copper amine oxidases (en) Nejnovější poznatky o substrátech a inhibitorech rostlinných aminoxidas obsahujících měď (cs)
skos:notation	RIV/61989592:15310/02:00001661!RIV/2005/GA0/153105/N
http://linked.open.../vavai/riv/strany	37
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/00/D119), Z(MSM 153100010)
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Peč, Pavel Šebela, Marek Lemr, Karel Frébort, Ivo Petřivalský, Marek
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	661611
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/02:00001661
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	amine;amine oxidase;enzyme;inhibitor;substrate (en)
http://linked.open.../riv/klicoveSlovo	amine amine oxidase substrate enzyme inhibitor
http://linked.open...ontrolniKodProRIV	[C0048430A0B0]
http://linked.open...i/riv/mistoVydani	Southampton
http://linked.open...i/riv/nazevZdroje	30rd International Symposium on Vitamin B6, PQQ, Carbonyl Catalysis and quinoproteins
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Structure and properties of endogenous amine oxidase inhibitor from bean seedlings and its analogues
http://linked.open...UplatneniVysledku	2002
http://linked.open...iv/tvurceVysledku	Lemr, Karel Petřivalský, Marek Šebela, Marek Frébort, Ivo Peč, Pavel Mlíčková, Kateřina Lamplot, Zbyněk
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20153100010
number of pages	60 (xsd:int)
http://purl.org/ne...btex#hasPublisher	University of Southampton
http://localhost/t...ganizacniJednotka	15310

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