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  • The innate immune system consists of functionally specialized %22modules%22 that are activated in response to a particular set of stimuli via sensors located on the surface or inside the tissue cells. These cells screen tissues for a wide range of exogenous and endogenous danger/damage-induced signals with the aim to reject or tolerate them and maintain tissue integrity. In this line of thinking, inflammation evolved as an adaptive tool for restoring tissue homeostasis. A number of diseases are mediated by a maladaptation of the innate immune response, perpetuating chronic inflammation and tissue damage. Here, we review recent evidence on the cross talk between innate immune sensors and development of rheumatoid arthritis, osteoarthritis, and aseptic loosening of total joint replacements. In relation to the latter topic, there is a growing body of evidence that aseptic loosening and periprosthetic osteolysis results from long-term maladaptation of periprosthetic tissues to the presence of by-products continuously released from an artificial joint.
  • The innate immune system consists of functionally specialized %22modules%22 that are activated in response to a particular set of stimuli via sensors located on the surface or inside the tissue cells. These cells screen tissues for a wide range of exogenous and endogenous danger/damage-induced signals with the aim to reject or tolerate them and maintain tissue integrity. In this line of thinking, inflammation evolved as an adaptive tool for restoring tissue homeostasis. A number of diseases are mediated by a maladaptation of the innate immune response, perpetuating chronic inflammation and tissue damage. Here, we review recent evidence on the cross talk between innate immune sensors and development of rheumatoid arthritis, osteoarthritis, and aseptic loosening of total joint replacements. In relation to the latter topic, there is a growing body of evidence that aseptic loosening and periprosthetic osteolysis results from long-term maladaptation of periprosthetic tissues to the presence of by-products continuously released from an artificial joint. (en)
Title
  • Innate Immunity Sensors Participating in Pathophysiology of Joint Diseases: A Brief Overview
  • Innate Immunity Sensors Participating in Pathophysiology of Joint Diseases: A Brief Overview (en)
skos:prefLabel
  • Innate Immunity Sensors Participating in Pathophysiology of Joint Diseases: A Brief Overview
  • Innate Immunity Sensors Participating in Pathophysiology of Joint Diseases: A Brief Overview (en)
skos:notation
  • RIV/61989592:15110/14:33153071!RIV15-MSM-15110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
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  • 21907
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/14:33153071
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • TLRs, NLRs, RAGE, CLRs, inflammasomes, rheumatoid arthritis, osteoarthritis, aseptic loosening; PRRs; innate immunity sensors (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [0B496B194842]
http://linked.open...i/riv/nazevZdroje
  • Journal of Long-Term Effects of Medical Implants
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 24
http://linked.open...iv/tvurceVysledku
  • Gallo, Jiří
  • Raška, Milan
  • Goodman, Stuart
  • Nich, Christophe
  • Konttinen, Yrjo
issn
  • 1050-6934
number of pages
http://bibframe.org/vocab/doi
  • 10.1615/JLongTermEffMedImplants.2014010825
http://localhost/t...ganizacniJednotka
  • 15110
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