About: Structural properties of CYP2D6: requirements for substrates and inhibitors

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.futuremedicine.com/doi/pdf/10.2217/fmeb2013.13.91
Description	CYP450 2D6 is a relatively flexible protein with plastic active site structure, allowing binding with high specificity of many different substrates of various sizes. Presence of a basic nitrogen atom at a distance of 5-7 ? from the site of metabolism is often found in the structure of typical substrates. After substrate binding, the active site structure is changed, embracing the substrate and fixing it in the optimal position for enzyme reaction. The alleles found in the human population that correspond to CYP450 2D6 variants with decreased enzymatic activity possess changed amino acids which, interestingly, do not directly participate in forming the active site. Instead, they probably take part in maintaining other properties of the enzyme, for example in the formation of solvent or substrate access channels. CYP450 2D6 is a relatively flexible protein with plastic active site structure, allowing binding with high specificity of many different substrates of various sizes. Presence of a basic nitrogen atom at a distance of 5-7 ? from the site of metabolism is often found in the structure of typical substrates. After substrate binding, the active site structure is changed, embracing the substrate and fixing it in the optimal position for enzyme reaction. The alleles found in the human population that correspond to CYP450 2D6 variants with decreased enzymatic activity possess changed amino acids which, interestingly, do not directly participate in forming the active site. Instead, they probably take part in maintaining other properties of the enzyme, for example in the formation of solvent or substrate access channels. (en)
Title	Structural properties of CYP2D6: requirements for substrates and inhibitors Structural properties of CYP2D6: requirements for substrates and inhibitors (en)
skos:prefLabel	Structural properties of CYP2D6: requirements for substrates and inhibitors Structural properties of CYP2D6: requirements for substrates and inhibitors (en)
skos:notation	RIV/61989592:15110/14:33150428!RIV15-MSM-15110___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GPP303/12/P019)
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	ANZENBACHER, Pavel Anzenbacherová, Eva
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	47880
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/14:33150428
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CYP2D6 inhibitors; CYP2D6 substrates; active site; cytochromes P450; CYP2D6 (en)
http://linked.open.../riv/klicoveSlovo	CYP2D6 inhibitors CYP2D6 substrates CYP2D6 cytochromes P450 active site
http://linked.open...ontrolniKodProRIV	[1203C57636FB]
http://linked.open...i/riv/mistoVydani	London
http://linked.open...vEdiceCisloSvazku	neuveden
http://linked.open...i/riv/nazevZdroje	CYP2D6: Genetics, Pharmacology and Clinical Relevance
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	153 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanism of ligand access/egress to/from active site of microsomal drug-metabolising cytochromes P450
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Otyepka, Michal Anzenbacher, Pavel Anzenbacherová, Eva Berka, Karel
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.2217/9781780844626
http://purl.org/ne...btex#hasPublisher	Future Medicine Ltd.
https://schema.org/isbn	978-1-78084-462-6
http://localhost/t...ganizacniJednotka	15110

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