About: Gastrointestinal stromal tumour: From the clinic to the molecules

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://nobleresearch.org/Journals/JCRT/Volume2/2052-4994-2014-8.aspx
Description	GastroIntestional stromal tumours (GISTs), the most frequent sarcoma in the gastro-intestinal (GI) tract, are highly resistant to conventional chemotherapy and radiotherapy. These tumours have activating mutations in two closely related genes, KIT (75-80%) or/and PDGFRA (5-10%). Targeting these mutated activated proteins with imatinib mesylate has proven efficient in the treatment of GISTs. The median survival after diagnosis of GIST increased from 1.5 to 4.8 years with imatinib treatment. However, resistance to imatinib eventually develops and new-targeted therapies are needed. This paper reviews the medical, clinical and pathological aspects of GISTs based on latest research in human cell lines and animal models. GastroIntestional stromal tumours (GISTs), the most frequent sarcoma in the gastro-intestinal (GI) tract, are highly resistant to conventional chemotherapy and radiotherapy. These tumours have activating mutations in two closely related genes, KIT (75-80%) or/and PDGFRA (5-10%). Targeting these mutated activated proteins with imatinib mesylate has proven efficient in the treatment of GISTs. The median survival after diagnosis of GIST increased from 1.5 to 4.8 years with imatinib treatment. However, resistance to imatinib eventually develops and new-targeted therapies are needed. This paper reviews the medical, clinical and pathological aspects of GISTs based on latest research in human cell lines and animal models. (en)
Title	Gastrointestinal stromal tumour: From the clinic to the molecules Gastrointestinal stromal tumour: From the clinic to the molecules (en)
skos:prefLabel	Gastrointestinal stromal tumour: From the clinic to the molecules Gastrointestinal stromal tumour: From the clinic to the molecules (en)
skos:notation	RIV/61989592:15110/14:33148908!RIV15-MSM-15110___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Hapková, Ilona Veselý, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	17950
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/14:33148908
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	imatinib mesylate; activating mutation; platelet-derived growth factor receptor alpha; KIT; smooth muscle cells; interstitial cells of cajal; gastrointestinal stromal tumours (en)
http://linked.open.../riv/klicoveSlovo	activating mutation interstitial cells of cajal platelet-derived growth factor receptor alpha smooth muscle cells imatinib mesylate KIT gastrointestinal stromal tumours
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[26F38B3AD0B9]
http://linked.open...i/riv/nazevZdroje	Journal of Cancer Research & Therapy
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Veselý, Jaroslav Barbara P, De Santa Florence, Bernex Hapková, Ilona
issn	2052-4994
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.14312/2052-4994.2014-8
http://localhost/t...ganizacniJednotka	15110

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