About: Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected Women.

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About: Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected Women. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Although sera and all external secretions contain antibodies to human immunodeficiency virus (HIV), their levels, specificity, isotypes, and relevant effector functions display a great degree of variability. Antibodies that bind HIV antigens and neutralize the virus are predominantly associated with the IgG isotype in sera and in all external secretions, even where total levels of IgG are much lower than those of IgA. Rectal fluid that contains high IgA, but low IgG levels, displayed low neutralizing activity independent of antibodies. Therefore, external secretions should be evaluated before and after selective depletion of Ig. At the systemic level, HIV-specific IgA may interfere with the effector functions of IgG, as suggested by recent studies of individuals systemically immunized with an experimental HIV vaccine. Although HIV-specific IgG and IgA antibodies may exhibit their protective activities at mucosal surfaces through interference with viral entry and local neutralization at the systemic level, such antibodies may display discordant effector functions. Although sera and all external secretions contain antibodies to human immunodeficiency virus (HIV), their levels, specificity, isotypes, and relevant effector functions display a great degree of variability. Antibodies that bind HIV antigens and neutralize the virus are predominantly associated with the IgG isotype in sera and in all external secretions, even where total levels of IgG are much lower than those of IgA. Rectal fluid that contains high IgA, but low IgG levels, displayed low neutralizing activity independent of antibodies. Therefore, external secretions should be evaluated before and after selective depletion of Ig. At the systemic level, HIV-specific IgA may interfere with the effector functions of IgG, as suggested by recent studies of individuals systemically immunized with an experimental HIV vaccine. Although HIV-specific IgG and IgA antibodies may exhibit their protective activities at mucosal surfaces through interference with viral entry and local neutralization at the systemic level, such antibodies may display discordant effector functions. (en)
Title	Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected Women. Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected Women. (en)
skos:prefLabel	Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected Women. Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected Women. (en)
skos:notation	RIV/61989592:15110/14:33148411!RIV15-MSM-15110___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	RAŠKA, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	20004
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/14:33148411
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HIV-Infected Women.; Mucosal Secretions; HIV; Humoral Immune Responses (en)
http://linked.open.../riv/klicoveSlovo	HIV HIV-Infected Women. Humoral Immune Responses Mucosal Secretions
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[46A007B7F2AE]
http://linked.open...i/riv/nazevZdroje	American Journal of Reproductive Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	71
http://linked.open...iv/tvurceVysledku	Moldoveanu, Zina Novák, Jan Raška, Milan Wei, Qing Mestecky, Jiří Alexander, Rashada
http://linked.open...ain/vavai/riv/wos	000335917600014
issn	1046-7408
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/aji.12203
http://localhost/t...ganizacniJednotka	15110

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