About: IgA Nephropathy: Molecular Mechanisms of the Disease

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Studies of molecular and cellular interactions involved in the pathogenesis of IgA nephropathy have revealed the autoimmune nature of this most common primary glomerulonephritis. In patients with this disease, altered glycan structures in the unique hinge region of the heavy chains of IgA1 molecules lead to the exposure of antigenic determinants, which are recognized by naturally occurring antiglycan antibodies of the IgG and/or IgA1 isotype. As a result, nephritogenic immune complexes form in the circulation and deposit in the glomerular mesangium. Deposited immune complexes induce proliferation of resident mesangial cells, increased production of extracellular matrix proteins and cytokines, and ultimately loss of glomerular function. Structural elucidation of the nature of these immune complexes and their biological activity should provide a rational basis for an effective, immunologically mediated inhibition of the formation of nephritogenic immune complexes that could be used as a disease-specific therapeutic approach. Studies of molecular and cellular interactions involved in the pathogenesis of IgA nephropathy have revealed the autoimmune nature of this most common primary glomerulonephritis. In patients with this disease, altered glycan structures in the unique hinge region of the heavy chains of IgA1 molecules lead to the exposure of antigenic determinants, which are recognized by naturally occurring antiglycan antibodies of the IgG and/or IgA1 isotype. As a result, nephritogenic immune complexes form in the circulation and deposit in the glomerular mesangium. Deposited immune complexes induce proliferation of resident mesangial cells, increased production of extracellular matrix proteins and cytokines, and ultimately loss of glomerular function. Structural elucidation of the nature of these immune complexes and their biological activity should provide a rational basis for an effective, immunologically mediated inhibition of the formation of nephritogenic immune complexes that could be used as a disease-specific therapeutic approach. (en)
Title	IgA Nephropathy: Molecular Mechanisms of the Disease IgA Nephropathy: Molecular Mechanisms of the Disease (en)
skos:prefLabel	IgA Nephropathy: Molecular Mechanisms of the Disease IgA Nephropathy: Molecular Mechanisms of the Disease (en)
skos:notation	RIV/61989592:15110/13:33140778!RIV14-MZ0-15110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	I P V
http://linked.open...avai/riv/aktivity	I, P(GAP302/10/1055), P(LH11046), P(NT11081), V
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	RAŠKA, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	78803
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/13:33140778
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	IgA nephropathy (en)
http://linked.open.../riv/klicoveSlovo	IgA nephropathy
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[94DA105E1BAD]
http://linked.open...i/riv/nazevZdroje	Annual Review of Pathology-Mechanisms of Disease
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of IgA1 glycosylation in IgA nephropathy The study of interactions among IgA1-glycosylating enzymes in IgA nephropathy Molecular approaches for elimination or inactivation of pathogenic circulating immune complexes in IgA nephropathy and Henoch-Schoenlein purpura.
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	2013
http://linked.open...iv/tvurceVysledku	Julian, Bruce Moldoveanu, Zina Novák, Jan Matoušovic, Karel Raška, Milan Městecký, Jiří Renfrow, Matthew Gharavi, Ali Novák, Lea
http://linked.open...ain/vavai/riv/wos	000318483400009
issn	1553-4006
number of pages	24 (xsd:int)
http://bibframe.org/vocab/doi	10.1146/annurev-pathol-011110-130216
http://localhost/t...ganizacniJednotka	15110

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