About: Erythropoietin-driven signaling ameliorates the survival defect of DMT1-mutant erythroid progenitors and erythroblasts

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About: Erythropoietin-driven signaling ameliorates the survival defect of DMT1-mutant erythroid progenitors and erythroblasts Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.haematologica.com/content/97/10/1480.full
Description	Hypochromic microcytic anemia associated with ineffective erythropoiesis caused by recessive mutations in divalent metal transporter 1 (DMT1) can be improved with high-dose erythropoietin supplementation. The aim of this study was to characterize and compare erythropoiesis in samples from a DMT1-mutant patient before and after treatment with erythropoietin, as well as in a mouse model with a DMT1 mutation, the mk/mk mice. We showed that erythropoietin inhibits apoptosis of DMT1-mutant erythroid progenitors and differentiating erythroblasts by increasing STAT5 signaling. Hypochromic microcytic anemia associated with ineffective erythropoiesis caused by recessive mutations in divalent metal transporter 1 (DMT1) can be improved with high-dose erythropoietin supplementation. The aim of this study was to characterize and compare erythropoiesis in samples from a DMT1-mutant patient before and after treatment with erythropoietin, as well as in a mouse model with a DMT1 mutation, the mk/mk mice. We showed that erythropoietin inhibits apoptosis of DMT1-mutant erythroid progenitors and differentiating erythroblasts by increasing STAT5 signaling. (en)
Title	Erythropoietin-driven signaling ameliorates the survival defect of DMT1-mutant erythroid progenitors and erythroblasts Erythropoietin-driven signaling ameliorates the survival defect of DMT1-mutant erythroid progenitors and erythroblasts (en)
skos:prefLabel	Erythropoietin-driven signaling ameliorates the survival defect of DMT1-mutant erythroid progenitors and erythroblasts Erythropoietin-driven signaling ameliorates the survival defect of DMT1-mutant erythroid progenitors and erythroblasts (en)
skos:notation	RIV/61989592:15110/12:33140231!RIV13-GA0-15110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GPP305/10/P210), S, Z(MSM6198959205)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Pospíšilová, Dagmar Doležal, Dalibor DIVOKÝ, Vladimír Horváthová, Monika Kapraľová, Katarína Židová, Zuzana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	134702
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/12:33140231
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	erythropoietin; ineffective erythropoiesis; apoptosis; DTM1 (en)
http://linked.open.../riv/klicoveSlovo	erythropoietin DTM1 ineffective erythropoiesis apoptosis
http://linked.open...odStatuVydavatele	IT - Italská republika
http://linked.open...ontrolniKodProRIV	[A6735F6B7A0E]
http://linked.open...i/riv/nazevZdroje	Haematologica: the hematology journal
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Consequences of DMT1 deficiency on erythropoiesis.
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	97
http://linked.open...iv/tvurceVysledku	Doležal, Dalibor Pospíšilová, Dagmar Divoký, Vladimír Horváthová, Monika Kapraľová, Katarína Židová, Zuzana
http://linked.open...ain/vavai/riv/wos	000310208400009
http://linked.open...n/vavai/riv/zamer	Studies of genes and molecular mechanisms involved in regulation of hematopoiesis, their clinical impact and targeted treatment
issn	0390-6078
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.3324/haematol.2011.059550
http://localhost/t...ganizacniJednotka	15110
is http://linked.open...avai/riv/vysledek of	Erythropoietin-driven signaling ameliorates the survival defect of DMT1-mutant erythroid progenitors and erythroblasts

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