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| Description
| - Investigations were performed to localize and analyze the botulinum toxin (BoNT-A) related changes of cerebral cortex activation in chronic stroke patients suffering from severe hand paralysis with arm spasticity. Effects on task- related cerebral activation were evaluated by functional magnetic resonance imaging (fMRI). Methods: 14 patients (5 males, 9 females,mean age 55.3 years) suffering from upper limb post-stroke spasticity were investigated. The change of armspasticitywas assessed by using the modified Ashworth scale (MAS). FMRI sessionswere performed before (W0), four weeks (W4) and 11 weeks (W11) after BoNT-A application. Patients were scannedwhile performing imaginarymovementwith the impaired hand. Group fMRI analysis included patient age as a covariate. Results: BoNT-A treatmentwas effective in alleviation of armspasticity. Mean MASwas at Week 0: 2.5 (SD 0.53), at Week 4: 1.45 (SD 0.38), at Week 11: 2.32 (SD 0.44). Task-related fMRI prior to the treatment showed extensive activation of bilateral frontoparietal sensorimotor cortical areas, anterior cingulate gyrus, pallidum, thalamus and cerebellum. Effective BoNT-A treatment (W4) resulted in partial reduction of active network volume inmost of the observed areas, whereas BoNT-free data (W11) revealed further volume reduction in the sensorimotor network. On direct comparison, significant activation decreases associated with BoNT-A treatment were located in areas outside the classical sensorimotor system, namely, ipsilesional lateral occipital cortex, supramarginal gyrus and precuneus cortex. On comparison of W4 and W11, no activation increases were found, instead, activation further decreased in ipsilesional insular cortex, contralesional superior frontal gyrus and bilateral frontal pole.
- Investigations were performed to localize and analyze the botulinum toxin (BoNT-A) related changes of cerebral cortex activation in chronic stroke patients suffering from severe hand paralysis with arm spasticity. Effects on task- related cerebral activation were evaluated by functional magnetic resonance imaging (fMRI). Methods: 14 patients (5 males, 9 females,mean age 55.3 years) suffering from upper limb post-stroke spasticity were investigated. The change of armspasticitywas assessed by using the modified Ashworth scale (MAS). FMRI sessionswere performed before (W0), four weeks (W4) and 11 weeks (W11) after BoNT-A application. Patients were scannedwhile performing imaginarymovementwith the impaired hand. Group fMRI analysis included patient age as a covariate. Results: BoNT-A treatmentwas effective in alleviation of armspasticity. Mean MASwas at Week 0: 2.5 (SD 0.53), at Week 4: 1.45 (SD 0.38), at Week 11: 2.32 (SD 0.44). Task-related fMRI prior to the treatment showed extensive activation of bilateral frontoparietal sensorimotor cortical areas, anterior cingulate gyrus, pallidum, thalamus and cerebellum. Effective BoNT-A treatment (W4) resulted in partial reduction of active network volume inmost of the observed areas, whereas BoNT-free data (W11) revealed further volume reduction in the sensorimotor network. On direct comparison, significant activation decreases associated with BoNT-A treatment were located in areas outside the classical sensorimotor system, namely, ipsilesional lateral occipital cortex, supramarginal gyrus and precuneus cortex. On comparison of W4 and W11, no activation increases were found, instead, activation further decreased in ipsilesional insular cortex, contralesional superior frontal gyrus and bilateral frontal pole. (en)
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| Title
| - BoNT-A related changes of cortical activity in patients suffering from severe hand
- BoNT-A related changes of cortical activity in patients suffering from severe hand (en)
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| skos:prefLabel
| - BoNT-A related changes of cortical activity in patients suffering from severe hand
- BoNT-A related changes of cortical activity in patients suffering from severe hand (en)
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| skos:notation
| - RIV/61989592:15110/12:33140001!RIV13-MZ0-15110___
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/12:33140001
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Botulinum toxin; Functional MRI; Arm spasticity; Stroke (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of the Neurological Sciences
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Zapletalová, Jana
- Herzig, Roman
- Kaňovský, Petr
- Král, Michal
- Hluštík, Petr
- Otruba, Pavel
- Veverka, Tomáš
- Hok, Pavel
- Tüdös, Zbyněk
- Krobot, Alois
- Tomášová, Zuzana
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
| - 10.1016/j.jns.2012.05.008
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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