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Description
| - The aims of this prospective study were to determine the prevalence of clinically silent rejection changes and of nephrotoxicity of calcineurin inhibitors among repeated protocol biopsies of transplanted kidneys and to assess their impacts on chronic graft function and damage at the end of 1 year. Subclinical rejection and toxic changes among a significant proportion of grafts are associated with progression of chronic changes already over the first year following transplantation. Hence they represent independent risk factors for the development of irreversible graft damage. Protocol biopsy seems to be an important method to monitor immunosuppressive therapy.
- The aims of this prospective study were to determine the prevalence of clinically silent rejection changes and of nephrotoxicity of calcineurin inhibitors among repeated protocol biopsies of transplanted kidneys and to assess their impacts on chronic graft function and damage at the end of 1 year. Subclinical rejection and toxic changes among a significant proportion of grafts are associated with progression of chronic changes already over the first year following transplantation. Hence they represent independent risk factors for the development of irreversible graft damage. Protocol biopsy seems to be an important method to monitor immunosuppressive therapy. (en)
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Title
| - Protocol biopsy of a transplanted kidney as a tool for monitoring adequacy of immunosupressive therapy: 10 years of experience from a single transplant center
- Protocol biopsy of a transplanted kidney as a tool for monitoring adequacy of immunosupressive therapy: 10 years of experience from a single transplant center (en)
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skos:prefLabel
| - Protocol biopsy of a transplanted kidney as a tool for monitoring adequacy of immunosupressive therapy: 10 years of experience from a single transplant center
- Protocol biopsy of a transplanted kidney as a tool for monitoring adequacy of immunosupressive therapy: 10 years of experience from a single transplant center (en)
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skos:notation
| - RIV/61989592:15110/11:33116438!RIV12-MSM-15110___
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http://linked.open...avai/predkladatel
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
| - Ciferská, Hana
- Horák, Pavel
- Zadražil, Josef
- Tichý, Tomáš
- Krejčí, Karel
- BACHLEDA, Petr
- Štrebl, Pavel
- Hrubý, Miroslav
- Žamboch, Kamil
- Horčička, Vladko
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/11:33116438
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - subclinical rejection; subclinical nephrotoxicity; renal graft damage; protocol biopsy; kidney transplantation; calcineurin inhibitors (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Transplantation Proceedings
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Ciferská, Hana
- Hrubý, Miroslav
- Horák, Pavel
- Tichý, Tomáš
- Zadražil, Josef
- Krejčí, Karel
- Al-Gabri, Sadek
- Bachleda, Petr
- Horčička, Vladko
- Štrebl, Pavel
- Žamboch, Kamil
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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is http://linked.open...avai/riv/vysledek
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