About: Detection of clopidogrel resistance by MEA and LTA

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Antiaggregation therapy is still the most frequently used approach to prevent thrombotic events in cardiovascular disease. It has a good clinical effect but there is increasing evidence of high residual platelet aggregation activity in a number of patients. Laboratory methods only allow us to detect clopidogrel %22non-responders%22 or %22low responders%22. Recent methods are based on monitoring residual platelet aggregation activity (aggregation methods) or detecting the number of free epitopes for binding a specific monoclonal antibody such as vasodilator-stimulated phosphoprotein phosphorylation (VASP). The aim of our study was the comparison of light transmission aggregometry (LTA) and multiple electrode platelet aggregometry (MEA) with induction by ADP at concentrations of 20 mýmol/L with or without prostaglandin E1 (PGE1). Antiaggregation therapy is still the most frequently used approach to prevent thrombotic events in cardiovascular disease. It has a good clinical effect but there is increasing evidence of high residual platelet aggregation activity in a number of patients. Laboratory methods only allow us to detect clopidogrel %22non-responders%22 or %22low responders%22. Recent methods are based on monitoring residual platelet aggregation activity (aggregation methods) or detecting the number of free epitopes for binding a specific monoclonal antibody such as vasodilator-stimulated phosphoprotein phosphorylation (VASP). The aim of our study was the comparison of light transmission aggregometry (LTA) and multiple electrode platelet aggregometry (MEA) with induction by ADP at concentrations of 20 mýmol/L with or without prostaglandin E1 (PGE1). (en)
Title	Detection of clopidogrel resistance by MEA and LTA Detection of clopidogrel resistance by MEA and LTA (en)
skos:prefLabel	Detection of clopidogrel resistance by MEA and LTA Detection of clopidogrel resistance by MEA and LTA (en)
skos:notation	RIV/61989592:15110/11:10223956!RIV12-MSM-15110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM6198959205)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	ÚLEHLOVÁ, Jana Galuszka, Jan KRČOVÁ, Věra HUTYRA, Martin Indráková, Jarmila Slavík, Luděk Hluší, Antonín INDRÁK, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	193699
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/11:10223956
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	platelet aggregation; multiple electrode aggregometry; clopidogrel; antiplatelet therapy (en)
http://linked.open.../riv/klicoveSlovo	platelet aggregation clopidogrel antiplatelet therapy multiple electrode aggregometry
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[E30E50355559]
http://linked.open...i/riv/nazevZdroje	Transfuze a hematologie dnes
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Galuszka, Jan Hutyra, Martin Indrák, Karel Krčová, Věra Slavík, Luděk Hluší, Antonín Indráková, Jarmila Úlehlová, Jana
http://linked.open...n/vavai/riv/zamer	Studies of genes and molecular mechanisms involved in regulation of hematopoiesis, their clinical impact and targeted treatment
issn	1213-5763
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	15110
is http://linked.open...avai/riv/vysledek of	Detection of clopidogrel resistance by MEA and LTA Detection of clopidogrel resistance by MEA and LTA

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