About: Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice

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About: Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	UV light is known to be implicated in several skin diseases. Through low molecular weight mediators, %22non-skin%22 tissues can also be affected. Female SKH-1 mice were exposed to a single dose of UVB (200, 800 mJ/cm(2)) or UVA (10, 20 J/cm(2)). Effects on haematological parameters, activity and/or expression of antioxidant enzymes, level of GSH, oxidative damage markers were analysed in blood, liver and skin. The blood count showed a significant increase in leukocyte number and reduction of platelets 4 h after UVA and UVB irradiation, which disappeared within 24 h except for the higher UVA dose. Changes in activity of catalase (CAT) and superoxide dismutase (SOD) and level of GSH and lipid peroxidation products were found in skin, erythrocytes and liver. Expression of CAT, SOD, glutathione transferase, nicotinamide adenine dinucleotide (phosphate) quinone oxidoreductase and hem oxygenase-1 in skin was affected after UVA and UVB radiation. Increase in carbonylated proteins was found in plasma and skin. UV light is known to be implicated in several skin diseases. Through low molecular weight mediators, %22non-skin%22 tissues can also be affected. Female SKH-1 mice were exposed to a single dose of UVB (200, 800 mJ/cm(2)) or UVA (10, 20 J/cm(2)). Effects on haematological parameters, activity and/or expression of antioxidant enzymes, level of GSH, oxidative damage markers were analysed in blood, liver and skin. The blood count showed a significant increase in leukocyte number and reduction of platelets 4 h after UVA and UVB irradiation, which disappeared within 24 h except for the higher UVA dose. Changes in activity of catalase (CAT) and superoxide dismutase (SOD) and level of GSH and lipid peroxidation products were found in skin, erythrocytes and liver. Expression of CAT, SOD, glutathione transferase, nicotinamide adenine dinucleotide (phosphate) quinone oxidoreductase and hem oxygenase-1 in skin was affected after UVA and UVB radiation. Increase in carbonylated proteins was found in plasma and skin. (en)
Title	Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice (en)
skos:prefLabel	Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice (en)
skos:notation	RIV/61989592:15110/11:10222123!RIV12-MSM-15110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP303/07/P314), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Rajnochová Svobodová, Alena Ulrichová, Jitka Šianská, Jarmila Galandáková, Adéla Vostálová, Jitka Doležal, Dalibor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	184535
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/11:10222123
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	oxidative stress; hairless mouse; acute toxicity; UVA; UVB (en)
http://linked.open.../riv/klicoveSlovo	UVA UVB acute toxicity hairless mouse oxidative stress
http://linked.open...odStatuVydavatele	JP - Japonsko
http://linked.open...ontrolniKodProRIV	[A09BD7FE8F8F]
http://linked.open...i/riv/nazevZdroje	Biological & Pharmaceutical Bulletin
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Photoprotective effects of natural plant phenolics in vitro and in vivo
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Doležal, Dalibor Galandáková, Adéla Rajnochová Svobodová, Alena Ulrichová, Jitka Vostálová, Jitka Šianská, Jarmila
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0918-6158
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	15110
is http://linked.open...avai/riv/vysledek of	Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice

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