About: Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and , and TP53 gene mutation

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About: Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and , and TP53 gene mutation Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Stable cell lines obtained by spontaneous immortalization might represent early stages of malignant transformation and be useful experimental models for studies of mechanisms of cancer development. The FHC (fetal human cells) cell line has been established from normal fetal colonic mucosa. Detailed characterization of this cell line and mechanism of spontaneously acquired immortality have not been described yet. Therefore, wecharacterized theFHCcell line in terms of its tumorigenicity, cytogenetics, and TP53 gene mutation analysis. FHC cells displayed capability for anchorage-independent growth in semisolid media in vitro and formed solid tumors after transplantation into SCID (severe combined immunodeficiency) mice. This tumorigenic phenotype was associated with hypotriploidy and chromosome number ranging from 66 to 69. Results of comparative genetic hybridization arrays showed that most chromosomes included regions of copy number gains or losses. Stable cell lines obtained by spontaneous immortalization might represent early stages of malignant transformation and be useful experimental models for studies of mechanisms of cancer development. The FHC (fetal human cells) cell line has been established from normal fetal colonic mucosa. Detailed characterization of this cell line and mechanism of spontaneously acquired immortality have not been described yet. Therefore, wecharacterized theFHCcell line in terms of its tumorigenicity, cytogenetics, and TP53 gene mutation analysis. FHC cells displayed capability for anchorage-independent growth in semisolid media in vitro and formed solid tumors after transplantation into SCID (severe combined immunodeficiency) mice. This tumorigenic phenotype was associated with hypotriploidy and chromosome number ranging from 66 to 69. Results of comparative genetic hybridization arrays showed that most chromosomes included regions of copy number gains or losses. (en)
Title	Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and , and TP53 gene mutation Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and , and TP53 gene mutation (en)
skos:prefLabel	Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and , and TP53 gene mutation Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and , and TP53 gene mutation (en)
skos:notation	RIV/61989592:15110/10:10213292!RIV11-GA0-15110___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA305/09/1216), S, Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vydra, David Hajdúch, Marián Trojanec, Radek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	259025
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/10:10213292
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mutation; gene; TP53; cell line; fetal colon (en)
http://linked.open.../riv/klicoveSlovo	gene TP53 mutation fetal colon cell line
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[723FCD1D89C3]
http://linked.open...i/riv/nazevZdroje	Cancer Genetics and Cytogenetics
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of mechnism of action and structure optimalization of triterpenoids with anti-tumor activity.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	197
http://linked.open...iv/tvurceVysledku	Brázdová, Marie Hajdúch, Marián Hofmanová, Jiřina Kozubík, Alois Pernicová, Zuzana Souček, Karel Hýžďalová, Martina Kočí, Lenka Trojanec, Radek Vydra, David Gajdušková, Pavla Lentvorská, Lenka
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0165-4608
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	15110
is http://linked.open...avai/riv/vysledek of	Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and , and TP53 gene mutation Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and , and TP53 gene mutation Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and , and TP53 gene mutation

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