About: Preparation of new 18a-oleanane alcohols: synthesis, characterization, and cytotoxic activity     Goto   Sponge   NotDistinct   Permalink

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  • New oleanane alcohols and their acetates were prepared using classical reductive reagents (LiAlH4, NaBH4, and B2H6-DMS). In this research, we also studied the influence of these reagents on the stereoselectivity of reduction. All compounds prepared were fully characterized by 1H and 13C NMR spectra, IR spectra, MS, and elemental analysis. These products were tested for cytotoxic activity against T-lymphoblastic leukemia (CEM), human erythromyeloblastoid leukemia (K562), and human melanoma (SK-MEL1) cell lines. One of the compounds prepared exhibits significant cytotoxic activity against the mesenchymal type of cancer cell lines.
  • New oleanane alcohols and their acetates were prepared using classical reductive reagents (LiAlH4, NaBH4, and B2H6-DMS). In this research, we also studied the influence of these reagents on the stereoselectivity of reduction. All compounds prepared were fully characterized by 1H and 13C NMR spectra, IR spectra, MS, and elemental analysis. These products were tested for cytotoxic activity against T-lymphoblastic leukemia (CEM), human erythromyeloblastoid leukemia (K562), and human melanoma (SK-MEL1) cell lines. One of the compounds prepared exhibits significant cytotoxic activity against the mesenchymal type of cancer cell lines. (en)
Title
  • Preparation of new 18a-oleanane alcohols: synthesis, characterization, and cytotoxic activity
  • Preparation of new 18a-oleanane alcohols: synthesis, characterization, and cytotoxic activity (en)
skos:prefLabel
  • Preparation of new 18a-oleanane alcohols: synthesis, characterization, and cytotoxic activity
  • Preparation of new 18a-oleanane alcohols: synthesis, characterization, and cytotoxic activity (en)
skos:notation
  • RIV/61989592:15110/10:10213231!RIV11-GA0-15110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA305/09/1216), S, Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 281377
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/10:10213231
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Cytotoxicity; Configuration; Ketone; Hydride; Reduction (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [09947E5F5669]
http://linked.open...i/riv/nazevZdroje
  • Monatschefte für Chemie
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 141
http://linked.open...iv/tvurceVysledku
  • Hajdúch, Marián
  • Kvasnica, Miroslav
  • Šarek, Jan
  • Rudovská, Iva
http://linked.open...n/vavai/riv/zamer
issn
  • 0026-9247
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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