About: THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL

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About: THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Silymarin has anti-proliferative and anti-angiogenic activities in-xenografts of human prostate cancer (PCa). Low dietary selenium on the other hand has been associated with increased-incidence of PCa. The purpose of the current trial was to determine whether a daily administration of a silymarin and-selenium (SM-Se) combination for 6 months would alter basic clinical chemistry and oxidative stress markers, and-improve the quality of life score (QoL) in men after radical prostatectomy (RP). The selected combination of silymarin and selenium significantly reduced two markers of lipid metabolism-known to be associated with PCa progression, LDL and total cholesterol in the blood of men after RP. This-suggests that this combination may be effective in reducing PCa progression. Silymarin has anti-proliferative and anti-angiogenic activities in-xenografts of human prostate cancer (PCa). Low dietary selenium on the other hand has been associated with increased-incidence of PCa. The purpose of the current trial was to determine whether a daily administration of a silymarin and-selenium (SM-Se) combination for 6 months would alter basic clinical chemistry and oxidative stress markers, and-improve the quality of life score (QoL) in men after radical prostatectomy (RP). The selected combination of silymarin and selenium significantly reduced two markers of lipid metabolism-known to be associated with PCa progression, LDL and total cholesterol in the blood of men after RP. This-suggests that this combination may be effective in reducing PCa progression. (en)
Title	THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL (en)
skos:prefLabel	THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL (en)
skos:notation	RIV/61989592:15110/10:10212887!RIV11-MSM-15110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vidlář, Aleš Študent, Vladimír Šimánek, Vilím Ulrichová, Jitka Vostálová, Jitka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	286256
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/10:10212887
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Blood cholesterol; Plasma lipoproteins; Clinical chemistry; Radical prostatectomy; Prostate cancer; Selenium (en)
http://linked.open.../riv/klicoveSlovo	Radical prostatectomy Prostate cancer Blood cholesterol Clinical chemistry Plasma lipoproteins Selenium
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[9EE00D481C7F]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	2010
http://linked.open...iv/tvurceVysledku	Ulrichová, Jitka Vostálová, Jitka Vidlář, Aleš Šimánek, Vilím Študent, Vladimír Vrbková, Jana Krajíček, Jiří
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1213-8118
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	15110
is http://linked.open...avai/riv/vysledek of	THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL

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