About: Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk.

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About: Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In the kidney vitamin D is converted to its active form. Since vitamin D exerts its activity through binding to the nuclear vitamin D receptor (VDR), most genetic studies have primarily focused on variation within this gene. Therefore, analysis of genetic variation in VDR and other vitamin D pathway genes may provide insight into the role of vitamin D in renal cell carcinoma (RCC) etiology. RCC cases (N = 777) and controls (N = 1,035) were genotyped to investigate the relationship between RCC risk and variation in eight target genes. Minimum-p-value permutation (Min-P) tests were used to identify genes associated with risk. A three single nucleotide polymorphism (SNP) sliding window was used to identify chromosomal regions with a False Discovery Rate of <10%, where subsequently, haplotype relative risks were computed in Haplostats. Min-P values showed that VDR (p-value = 0.02) and retinoid-X-receptor-alpha (RXRA) (p-value = 0.10) were associated with RCC risk. Within VDR, three haplotypes across tw In the kidney vitamin D is converted to its active form. Since vitamin D exerts its activity through binding to the nuclear vitamin D receptor (VDR), most genetic studies have primarily focused on variation within this gene. Therefore, analysis of genetic variation in VDR and other vitamin D pathway genes may provide insight into the role of vitamin D in renal cell carcinoma (RCC) etiology. RCC cases (N = 777) and controls (N = 1,035) were genotyped to investigate the relationship between RCC risk and variation in eight target genes. Minimum-p-value permutation (Min-P) tests were used to identify genes associated with risk. A three single nucleotide polymorphism (SNP) sliding window was used to identify chromosomal regions with a False Discovery Rate of <10%, where subsequently, haplotype relative risks were computed in Haplostats. Min-P values showed that VDR (p-value = 0.02) and retinoid-X-receptor-alpha (RXRA) (p-value = 0.10) were associated with RCC risk. Within VDR, three haplotypes across tw (en)
Title	Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk. Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk. (en)
skos:prefLabel	Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk. Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk. (en)
skos:notation	RIV/61989592:15110/09:00009813!RIV10-MZ0-15110___
http://linked.open...avai/riv/aktivita	P V
http://linked.open...avai/riv/aktivity	P(NS10290), V
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Janout, Vladimír Kollárová, Helena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	302933
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/09:00009813
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SNP; vitamin D; renal cancer risk (en)
http://linked.open.../riv/klicoveSlovo	SNP renal cancer risk vitamin D - vitamin D receptor - sarcopenia - cardiac failure - dementia - depression
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[52D8C8958B58]
http://linked.open...i/riv/nazevZdroje	P L o S One
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Epidemiologic study of genetic and behavioral risk factors in kidney cancer
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Janout, Vladimír Kollárová, Helena Navrátilová, Marie Brennan, Paul Karami, Sara Mates, Dana Zaridze, David Rosenberg, Philip S.
issn	1932-6203
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	15110
is http://linked.open...avai/riv/vysledek of	Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk. Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk. Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk. Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk.

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