About: The relationship between some soluble osteogenic markers, angiogenic cytokines/other biological parameters and the stages of multiple myeloma evaluated according to the Durie-Salmon and International prognostic index stratification systems

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About: The relationship between some soluble osteogenic markers, angiogenic cytokines/other biological parameters and the stages of multiple myeloma evaluated according to the Durie-Salmon and International prognostic index stratification systems Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: The aim of the present paper was to study correlation between serum concentrations of levels of 12 soluble biological markers and myeloma stage evaluated according to Durie-Salmon (D-S) and International Prognostic Index (IPI) stratification systems. Methods: We analyzed a non-pretreated group of 179 patients with MM stratified according to D-S and IPI. Serum levels of soluble biological markers were evaluated using ELISA, REA and quantitative sandwich enzymatic immunoassays, the obtained results were analyzed by Kruskal-Wallis and Mann-Whitney tests. Results: The staging system according to D-S revealed a highly significant relationship between all stages (I-III) in case of beta2-m (p<0.0001) and sTK (p<0.001), in sICTP a significant difference was found only in stages II vs III (p<0.001) and I vs III (p<0.001), in case of sCD138 (syndecan-1) in stages I vs II (p = 0.006) and I vs III (p<0.001), in sVEGF only in stages I vs III (p = 0.006). In substages A vs B we found s Background: The aim of the present paper was to study correlation between serum concentrations of levels of 12 soluble biological markers and myeloma stage evaluated according to Durie-Salmon (D-S) and International Prognostic Index (IPI) stratification systems. Methods: We analyzed a non-pretreated group of 179 patients with MM stratified according to D-S and IPI. Serum levels of soluble biological markers were evaluated using ELISA, REA and quantitative sandwich enzymatic immunoassays, the obtained results were analyzed by Kruskal-Wallis and Mann-Whitney tests. Results: The staging system according to D-S revealed a highly significant relationship between all stages (I-III) in case of beta2-m (p<0.0001) and sTK (p<0.001), in sICTP a significant difference was found only in stages II vs III (p<0.001) and I vs III (p<0.001), in case of sCD138 (syndecan-1) in stages I vs II (p = 0.006) and I vs III (p<0.001), in sVEGF only in stages I vs III (p = 0.006). In substages A vs B we found s (en)
Title	The relationship between some soluble osteogenic markers, angiogenic cytokines/other biological parameters and the stages of multiple myeloma evaluated according to the Durie-Salmon and International prognostic index stratification systems The relationship between some soluble osteogenic markers, angiogenic cytokines/other biological parameters and the stages of multiple myeloma evaluated according to the Durie-Salmon and International prognostic index stratification systems (en)
skos:prefLabel	The relationship between some soluble osteogenic markers, angiogenic cytokines/other biological parameters and the stages of multiple myeloma evaluated according to the Durie-Salmon and International prognostic index stratification systems The relationship between some soluble osteogenic markers, angiogenic cytokines/other biological parameters and the stages of multiple myeloma evaluated according to the Durie-Salmon and International prognostic index stratification systems (en)
skos:notation	RIV/61989592:15110/09:00009806!RIV10-MZ0-15110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9489), P(NR9500)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Langová, Kateřina Ščudla, Vlastimil Bačovský, Jaroslav Pika, Tomáš Minařík, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	338787
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/09:00009806
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Multiple myeloma; Durie-Salmon staging system; International Prognostic Index; beta2-microglobulin; /thymidinekinase; sICTP; sHGF; sCD138(syndecan-1) (en)
http://linked.open.../riv/klicoveSlovo	beta2-microglobulin Multiple myeloma /thymidinekinase Durie-Salmon staging system International Prognostic Index sCD138(syndecan-1) sHGF sICTP
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[1EDC9C452E7D]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Significance of 18F-FDG PET/CT, whole body MRI and 99mTc-MIBI scintigraphy in diagnosis, clinical staging and monitoring of course of multiple myeloma Angiogenesis, plasma cell kinetics, parameters of microenvironments of bone marrow and bone metabolism in monoclonal gammopathy of undetermined significance and initial phases of multiple myeloma
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	153
http://linked.open...iv/tvurceVysledku	Budíková, Marie Langová, Kateřina Petrová, Pavla Pika, Tomáš Ščudla, Vlastimil Bačovský, Jaroslav Minařík, Jiří Srovnalík, Karel
issn	1213-8118
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	15110
is http://linked.open...avai/riv/vysledek of	The relationship between some soluble osteogenic markers, angiogenic cytokines/other biological parameters and the stages of multiple myeloma evaluated according to the Durie-Salmon and International prognostic index stratification systems The relationship between some soluble osteogenic markers, angiogenic cytokines/other biological parameters and the stages of multiple myeloma evaluated according to the Durie-Salmon and International prognostic index stratification systems The relationship between some soluble osteogenic markers, angiogenic cytokines/other biological parameters and the stages of multiple myeloma evaluated according to the Durie-Salmon and International prognostic index stratification systems The relationship between some soluble osteogenic markers, angiogenic cytokines/other biological parameters and the stages of multiple myeloma evaluated according to the Durie-Salmon and International prognostic index stratification systems

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