About: Improvement of cardiovascular risk factors and cosmetic side effects in kidney transplant recipients after conversion to tacrolimus     Goto   Sponge   NotDistinct   Permalink

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  • Aims: Tacrolimus and cyclosporine A (CyA) are cornerstones in immunosuppressive therapy. Cyclosporine side effects include hypertension and hypercholesterolemia both of which may increase the risk of cardiovascular mortality, gingival hyperplasia and hirsutism are known to reduce quality of life. The aim of this prespective study was to evaluate changes in cardiovascular risk profile and cosmetic side effects after conversion from CyA to tacrolimus. Methods: 25 stable kidney transplant recipients (9 male, 16 female) were converted froma a CyA to a tacrolimus - based regimen. Mean age was 45,7 +- 13,5 years. Time to switch following transplantation was 4,8+-1,7 years. Resons for conversion were multiple: arterial hypertension (9), hypertrichosis (3), gingival hyperplasia (3), hyperlipidemia (14). Results: 19/25 patients completed the one year study period. One patient died, two returned to hemodialysis. two were switched back to CyA and one patient was lost to follow-up. there were statistically sign
  • Aims: Tacrolimus and cyclosporine A (CyA) are cornerstones in immunosuppressive therapy. Cyclosporine side effects include hypertension and hypercholesterolemia both of which may increase the risk of cardiovascular mortality, gingival hyperplasia and hirsutism are known to reduce quality of life. The aim of this prespective study was to evaluate changes in cardiovascular risk profile and cosmetic side effects after conversion from CyA to tacrolimus. Methods: 25 stable kidney transplant recipients (9 male, 16 female) were converted froma a CyA to a tacrolimus - based regimen. Mean age was 45,7 +- 13,5 years. Time to switch following transplantation was 4,8+-1,7 years. Resons for conversion were multiple: arterial hypertension (9), hypertrichosis (3), gingival hyperplasia (3), hyperlipidemia (14). Results: 19/25 patients completed the one year study period. One patient died, two returned to hemodialysis. two were switched back to CyA and one patient was lost to follow-up. there were statistically sign (en)
Title
  • Improvement of cardiovascular risk factors and cosmetic side effects in kidney transplant recipients after conversion to tacrolimus
  • Improvement of cardiovascular risk factors and cosmetic side effects in kidney transplant recipients after conversion to tacrolimus (en)
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  • Improvement of cardiovascular risk factors and cosmetic side effects in kidney transplant recipients after conversion to tacrolimus
  • Improvement of cardiovascular risk factors and cosmetic side effects in kidney transplant recipients after conversion to tacrolimus (en)
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  • RIV/61989592:15110/09:00009787!RIV10-MZ0-15110___
http://linked.open...avai/riv/aktivita
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  • 318827
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  • RIV/61989592:15110/09:00009787
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  • renal transplantation; cardiovascular mortality; hypertension; hyperlipidemia; side effects; cyclosporine; tacrolimus (en)
http://linked.open.../riv/klicoveSlovo
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  • CZ - Česká republika
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  • [C5ECD6F03843]
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  • Biomedical Papers
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  • 153
http://linked.open...iv/tvurceVysledku
  • Horák, Pavel
  • Zadražil, Josef
  • Zahálková, Jana
  • Valkovský, Ivo
  • Krejčí, Karel
  • Dědochová, Jarmila
  • Bachleda, Petr
  • Horčička, Vladko
  • Štrebl, Pavel
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  • 1213-8118
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  • 15110
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