About: Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic haematopoietic stem cell transplantation     Goto   Sponge   NotDistinct   Permalink

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  • Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic haematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. Three MADCAM1 gene single nucleotide polymorphisms (rs758502 C/T, rs2302217 A/G, rs3745925 G/T) were genotyped by polymerase chain reaction with sequence-specific primers in 87 Czech, HLA-identical donor-recipient aHSCT pairs. MADCAM1 rs2302217 AA homozygous recipients developed chronic GVHD more frequently than patients with other genotypes (65% vs. 34%; p = 0.025). Furthermore, multivariate analysis revealed the MADCAM1 rs2302217 AA genotype in recipient being also an independent factor associated with development of acute GVHD (p = 0.036) and decreased overall survival (p = 0.001). These data suggest that MADCA
  • Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic haematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. Three MADCAM1 gene single nucleotide polymorphisms (rs758502 C/T, rs2302217 A/G, rs3745925 G/T) were genotyped by polymerase chain reaction with sequence-specific primers in 87 Czech, HLA-identical donor-recipient aHSCT pairs. MADCAM1 rs2302217 AA homozygous recipients developed chronic GVHD more frequently than patients with other genotypes (65% vs. 34%; p = 0.025). Furthermore, multivariate analysis revealed the MADCAM1 rs2302217 AA genotype in recipient being also an independent factor associated with development of acute GVHD (p = 0.036) and decreased overall survival (p = 0.001). These data suggest that MADCA (en)
Title
  • Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic haematopoietic stem cell transplantation
  • Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic haematopoietic stem cell transplantation (en)
skos:prefLabel
  • Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic haematopoietic stem cell transplantation
  • Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic haematopoietic stem cell transplantation (en)
skos:notation
  • RIV/61989592:15110/09:00009718!RIV10-MSM-15110___
http://linked.open...avai/riv/aktivita
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  • S, Z(MSM6198959205)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 334601
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  • RIV/61989592:15110/09:00009718
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  • Graft-versus-host disease; haematopoietic stem cell transplantation; MAdCAM-1; single nucleotide polymorphisms; overall survival. (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [77ACDABF1317]
http://linked.open...i/riv/nazevZdroje
  • Human Immunology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 70
http://linked.open...iv/tvurceVysledku
  • Faber, Edgar
  • Indrák, Karel
  • Mrázek, František
  • Petřek, Martin
  • Raida, Luděk
  • Sťahelová, Anna
  • Ambrůzová, Zuzana
http://linked.open...n/vavai/riv/zamer
issn
  • 0198-8859
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  • 15110
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