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  • The aim of the present study was to investigate the antioxidant effect of the flavonoid osajin isolated from the infructences of Maclura pomifera, Moraceae, against the damage inflicted by ROS in a rat model of renal ischemia-reperfusion injury. Renal ischemia-reperfusion was induced by clamping unilateral renal artery for 60 minutes. Renal function was assessed by estimating serum creatinine, blood urea nitrogen and creatinine clearance. Renal morphological alterations were assessed by histopathological examination of hematoxylin-eosin stained sections of the kidneys. Ischemia-reperfusion produced elevated levels of malondialdehyde (a metabolic marker of lipid peroxidation), decreased the total antioxidant activity and deteriorated the renal function as assessed by increased serum creatinine, blood urea nitrogen and decreased creatinine clearance as compared to control rats. The ischemie kidneys of rats showed severe hyaline casts, epithelial swelling,proteinaceous debris, tubular necrosis, medullar
  • The aim of the present study was to investigate the antioxidant effect of the flavonoid osajin isolated from the infructences of Maclura pomifera, Moraceae, against the damage inflicted by ROS in a rat model of renal ischemia-reperfusion injury. Renal ischemia-reperfusion was induced by clamping unilateral renal artery for 60 minutes. Renal function was assessed by estimating serum creatinine, blood urea nitrogen and creatinine clearance. Renal morphological alterations were assessed by histopathological examination of hematoxylin-eosin stained sections of the kidneys. Ischemia-reperfusion produced elevated levels of malondialdehyde (a metabolic marker of lipid peroxidation), decreased the total antioxidant activity and deteriorated the renal function as assessed by increased serum creatinine, blood urea nitrogen and decreased creatinine clearance as compared to control rats. The ischemie kidneys of rats showed severe hyaline casts, epithelial swelling,proteinaceous debris, tubular necrosis, medullar (en)
Title
  • The role of flavonoid osajin in renal ischemia-reperfusion model
  • The role of flavonoid osajin in renal ischemia-reperfusion model (en)
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  • The role of flavonoid osajin in renal ischemia-reperfusion model
  • The role of flavonoid osajin in renal ischemia-reperfusion model (en)
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  • RIV/61989592:15110/09:00009545!RIV10-MSM-15110___
http://linked.open...avai/riv/aktivita
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  • 339708
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  • RIV/61989592:15110/09:00009545
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  • osajin; Maclura pomifera; antioxidant; renal ischemia-reperfusion; free oxygen radicals (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
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  • [5FA6DBA2C098]
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  • Česká a slovenská farmacie
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http://linked.open...v/svazekPeriodika
  • 58
http://linked.open...iv/tvurceVysledku
  • Bartošík, Tomáš
  • Nečas, Jiří
  • Pavlík, Martin
  • Bartošíková, Lenka
  • Fráňa, Pavel
issn
  • 1210-7816
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  • 15110
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