About: Bone remodeling, particle disease and individual suspectibility to periprosthetic osteolysis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bone remodeling is a tighitly coupled process consisting of repetitive cycles of bone resorption and formation. Both processes are governed by mechanical signals, with operate in conjuction with local and systemic factors in a discrete anatomic structure designated a basic multicellular unit (BMU). The microenvironment around total joint arthroplasty is a dynamic and complex milieu influence by the chemical and physical stimuli associated with servicing the prosthesis. A key factor limiting the longevity of the prosthesis is polyethylene wear, which induces particle disease, and this maylead to increased and prolonged activity of BMUs resulting in periprosthetic osteolysis. Several pathways regulating BMU function have reported the past, including RANKL/RANK/TRAF6, TNF-alpha/TNFR/TRAF1, and IL-6/CD126/JAK/STAT. Moreover, the expressions and functional activity of all these Molecules can be affected by variations in their genes. These may explai the differences in severity of bone defects or prosthetic failure between with similar wear retes and the same prosthesis. Simultaneously, this data strongly support the theory of individual susceptibility to prosthetic failure. Bone remodeling is a tighitly coupled process consisting of repetitive cycles of bone resorption and formation. Both processes are governed by mechanical signals, with operate in conjuction with local and systemic factors in a discrete anatomic structure designated a basic multicellular unit (BMU). The microenvironment around total joint arthroplasty is a dynamic and complex milieu influence by the chemical and physical stimuli associated with servicing the prosthesis. A key factor limiting the longevity of the prosthesis is polyethylene wear, which induces particle disease, and this maylead to increased and prolonged activity of BMUs resulting in periprosthetic osteolysis. Several pathways regulating BMU function have reported the past, including RANKL/RANK/TRAF6, TNF-alpha/TNFR/TRAF1, and IL-6/CD126/JAK/STAT. Moreover, the expressions and functional activity of all these Molecules can be affected by variations in their genes. These may explai the differences in severity of bone defects or prosthetic failure between with similar wear retes and the same prosthesis. Simultaneously, this data strongly support the theory of individual susceptibility to prosthetic failure. (en)
Title	Bone remodeling, particle disease and individual suspectibility to periprosthetic osteolysis Bone remodeling, particle disease and individual suspectibility to periprosthetic osteolysis (en)
skos:prefLabel	Bone remodeling, particle disease and individual suspectibility to periprosthetic osteolysis Bone remodeling, particle disease and individual suspectibility to periprosthetic osteolysis (en)
skos:notation	RIV/61989592:15110/08:33117551!RIV12-MSM-15110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6198959223)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Petřek, Martin Mrázek, František Gallo, Jiří RAŠKA, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	358372
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/08:33117551
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	osteoblas; osteoclast; basic multicellular unit; particle disease; periprothetic osteolysis (en)
http://linked.open.../riv/klicoveSlovo	osteoclast basic multicellular unit osteoblas particle disease periprothetic osteolysis
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[327964A1D384]
http://linked.open...i/riv/nazevZdroje	Physiological Research (print)
http://linked.open...in/vavai/riv/obor	FI
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Gallo, Jiří Mrázek, František Petřek, Martin Raška, Milan
http://linked.open...n/vavai/riv/zamer	Nové možnosti diagnostiky a imunomodulace u infekčních onemocnění a imunopatologických stavů
issn	0862-8408
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	15110
is http://linked.open...avai/riv/vysledek of	Bone remodeling, particle disease and individual suspectibility to periprosthetic osteolysis Bone remodeling, particle disease and individual suspectibility to periprosthetic osteolysis

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