About: Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study.

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About: Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Exposure to UVA radiation is known to cause many adverse biological effects by inducing the stricken cells to produce reactive oxygen species (ROS). In recent years the use of botanicals has received considerable interest in the skin protection. Bilberry (Vaccinium myrtillus L.) fruit contains several polyphenols with strong antioxidant and anti-inflammatory properties. In this study we evaluated potential UVA preventive effect of V. myrtillus fruit extract (VME; anthocyanins, 25 % w/w) in HaCaT keratinocytes. Pre-treatment (1 h) or post-treatment (4 h) of HaCaT with VME resulted in attenuation of UVA-caused damage. Application of the extract significantly reduced UVA-stimulated ROS formation in keratinocytes. VME also prevented/reduced UVA-caused peroxidation of membrane lipids and depletion of intracellular GSH. The observed cytoprotective effect may be linked to the antioxidant activity of the plant constituents, namely anthocyanins. Exposure to UVA radiation is known to cause many adverse biological effects by inducing the stricken cells to produce reactive oxygen species (ROS). In recent years the use of botanicals has received considerable interest in the skin protection. Bilberry (Vaccinium myrtillus L.) fruit contains several polyphenols with strong antioxidant and anti-inflammatory properties. In this study we evaluated potential UVA preventive effect of V. myrtillus fruit extract (VME; anthocyanins, 25 % w/w) in HaCaT keratinocytes. Pre-treatment (1 h) or post-treatment (4 h) of HaCaT with VME resulted in attenuation of UVA-caused damage. Application of the extract significantly reduced UVA-stimulated ROS formation in keratinocytes. VME also prevented/reduced UVA-caused peroxidation of membrane lipids and depletion of intracellular GSH. The observed cytoprotective effect may be linked to the antioxidant activity of the plant constituents, namely anthocyanins. (en)
Title	Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study. Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study. (en)
skos:prefLabel	Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study. Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study. (en)
skos:notation	RIV/61989592:15110/08:10213704!RIV12-MSM-15110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(FT-TA3/024), P(GP303/07/P314), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Walterová, Daniela Rajnochová Svobodová, Alena Vostálová, Jitka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	357967
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/08:10213704
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	free radicals; oxidative stress; HaCaT keratinocytes; UVA radiation; Vaccinium myrtillus (en)
http://linked.open.../riv/klicoveSlovo	UVA radiation free radicals oxidative stress Vaccinium myrtillus HaCaT keratinocytes
http://linked.open...odStatuVydavatele	JP - Japonsko
http://linked.open...ontrolniKodProRIV	[569294F7C6E2]
http://linked.open...i/riv/nazevZdroje	BioFactors
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Photoprotective effects of natural plant phenolics in vitro and in vivo Plant chemoprotectants - New food supplements for health and prevention of chronic diseases.
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Vostálová, Jitka Svobodová, Alena Walterová, Daniela Rambousková, Jana
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0951-6433
number of pages	18 (xsd:int)
http://localhost/t...ganizacniJednotka	15110
is http://linked.open...avai/riv/vysledek of	Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study. Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study.

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