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| Description
| - Objectives: Analysis of neutrophil levels in the saliva as the early marker of stem cells engraftment after autologous transplantation (ASCT) myelomas and lymphomas patients. Evaluation of risk factors for oral mucositis (OM) to improve stomatological care before transplantation. Methods: Results of prospective study (started January 2006) after obtaining ethics commitee approval are reported. 27 patients treated for multiple myeloma (MM), Hodgkin´s (MH) and non-hodgkins lymphoma (NHL) were stomatologically examined before, during and after planned high-dose chemotherapy with ASCT to evaluate OM according to NCI-CTC and WHO classfication.Before the beginning of hematooncological treatment all potential sources of odontogenic infection and/or local irritation of oral mucosa were removed. The conditioning regimen included high-dose melphalan for MM and BEAM regimen for NHL, MH. Supportive care was administered according to standard institutional practise. Neutrophil levels in saliva were monitored dail
- Objectives: Analysis of neutrophil levels in the saliva as the early marker of stem cells engraftment after autologous transplantation (ASCT) myelomas and lymphomas patients. Evaluation of risk factors for oral mucositis (OM) to improve stomatological care before transplantation. Methods: Results of prospective study (started January 2006) after obtaining ethics commitee approval are reported. 27 patients treated for multiple myeloma (MM), Hodgkin´s (MH) and non-hodgkins lymphoma (NHL) were stomatologically examined before, during and after planned high-dose chemotherapy with ASCT to evaluate OM according to NCI-CTC and WHO classfication.Before the beginning of hematooncological treatment all potential sources of odontogenic infection and/or local irritation of oral mucosa were removed. The conditioning regimen included high-dose melphalan for MM and BEAM regimen for NHL, MH. Supportive care was administered according to standard institutional practise. Neutrophil levels in saliva were monitored dail (en)
- Autologní transplantace, tj. podání vysocedávkované chemoterapie s podporou periferních kmenových buněk je standardní léčebnou metodou u pacientů s řadou hematologických malignit, nejčastěji pak s mnohotným myelomem a nonhodgkinským lymfomem. Závažným nežádoucím účinkem této léčby je přechodná myelosuprese a z ní vyplývající riziko infekčních komplikací, dále pak mucositida a stomatitida, které vedou k poruchám příjmu léků a živin a mají dopad na celkový stav nemocných. V prevenci vzniku stomatitidy je nezbytná intervence stomatologa - sanace odontogenních fokusů před transplantací a edukace pacienta v péči o dutinu ústní během transplantace. V léčbě rozvinuté stomatitidy jsou dosavadní léčebné metody většinou omezeny na symptomatickou léčbu. Naše snahy o zlepšení péče o nemocné se stomatitidou během autologní transplantace krvetvorných buněk jsou zaměřeny na zkoumání úlohy lokálních faktorů ve slinách nemocných. Ukazuje se, že významnou roli zde sehrávají granulocyty, které mohou být také časným uka (cs)
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| Title
| - The salivary neutrophil level as an early indicator of engraftment after autologous transplantation for myeloma and lymphoma. The role of patient education and preventive dentristry for oral mucositis rescue
- The salivary neutrophil level as an early indicator of engraftment after autologous transplantation for myeloma and lymphoma. The role of patient education and preventive dentristry for oral mucositis rescue (en)
- Význam stanovení hladiny leukocytů ve slině pro posouzení stomatitidy a přihojení štěpu u pacientů autologně transplantovaných pro myelom a lymfom. (cs)
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| skos:prefLabel
| - The salivary neutrophil level as an early indicator of engraftment after autologous transplantation for myeloma and lymphoma. The role of patient education and preventive dentristry for oral mucositis rescue
- The salivary neutrophil level as an early indicator of engraftment after autologous transplantation for myeloma and lymphoma. The role of patient education and preventive dentristry for oral mucositis rescue (en)
- Význam stanovení hladiny leukocytů ve slině pro posouzení stomatitidy a přihojení štěpu u pacientů autologně transplantovaných pro myelom a lymfom. (cs)
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| skos:notation
| - RIV/61989592:15110/08:00007541!RIV09-MSM-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/08:00007541
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - autologous transplantation (ASCT); oral mucositis (OM) (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Bone Marrow Transplantation
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Faber, Edgar
- Indrák, Karel
- Skoumalová, Ivana
- Vondráková, Jana
- Pazdera, Jindřich
- Pink, Richard
- Marešová, Ivana
- Koupilová, Milena
- Vítková, Jitka
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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